Abstract : Hygrophila erecta (Burm.f.) Hochr. belonging to the Acanthaceae family, is a moisture loving genera and a perennial herb whose seeds are used as a skin-regenerating product. The concentrated ethyl acetate soluble fraction of methanolic extract of this whole plant resulted in a mixture of a mixture of 4-methoxybenzoic acid and 4-methoxycinnamic acid, another mixture of two ester derivatives: methyl linoleate and methyl stearate, lupeol, β-Sitosterol and Stigmasterol. The crude methanolic extract of the whole plant was partitioned to petroleum ether soluble fraction, chloroform soluble fraction, ethyl acetate soluble fraction and aqueous soluble fraction for the purpose of investigations of different biological activities. The ethyl acetate soluble fraction expressed the highest antioxidant property in DPPH free radical scavanging method, whilst the different extractives exhibited moderate to strong cytotoxicity in brine shrimp lethality test and the highest activity was shown by pet ether soluble fraction. Furthermore, the pet ether soluble fraction also demonstrated highest thrombolytic activity compared to the standard streptokinase, while the other fractions showed moderate to lower activity. However, no antimicrobial activity was observed for any of the fractions investigated using standard tetracycline and ciprofloxacin. The methanolic extract further produced statistical significant peripheral analgesic and antidiarrheal activity at both 200 mg/kg and 400 mg/kg doses. Although, it expressed blood glucose lowering activity, but it was not statistical significant.

Keyword : Hygrophila erecta (Burm.f.) Hochr., Acanthaceae, Methyl linoleate and methyl stearate, 4-methoxybenzoic acid and 4-methoxycinnamic acid, Antioxidant, Cytotoxicity.

Abstract : Colorectal cancer one of the mostly found cancer in all over the world. Mortality rate by this cancer is high compared to other types o cancers. Early diagnosis of this cancer is required to treat this cancer. Many drugs are being used to treat this disease but they all have many side effects so in study we tried to overcome this issue by treating this cancer with supplements. We used male albino SD rats to conduct this study. We divided the rats into 7 groups in which 4 of them were given Azoxymethane (AOM) to induce the colo-rectal cancer while remaining 3 were kept control. One group with AOM was not given any treatment while 3 received folic acid dose (20, 40, and 60) respectively along with Vitamin A, C, and E supplementation. Control groups without AMO were also treated with same doses of folic acid in order to compare the results. Results reveal that Folic acid improved GSH, TAC, Lipid peroxidation and superoxide dismutase levels in the AMO treated groups. These tests were also improved in control groups with folic acid and vitamin supplementation. We conclude that Folic acid is found very affective against the colorectal cancer without harming the natural mechanisms in the body. The aim of this study, to evaluate the preventive and protective measure of different doses of folic acid with normal therapeutic doses of vitamin A, C and E against azoxymethane induce colon cancer in rat.

Keyword : Colon and rectum cancer, Folic acid, VitaminC, Azoxymethane, Superoxide dismutase, GSH

Abstract : As of early 2020, humanity is try an epidemic in severe acute metastasis syndrome coronavirus a combine of (SARS-CoV-2).SARS-CoV-2 causes coronavirus illness, abbreviated as COVID-19. With COVID-19, the degree of unhealthiness varies, starting from well to sharp and fatal. the planet Health Organization estimates that serious unhealthiness may occur in as many as 13.8% of cases and 6.1% unit of measurement essential. This Viewpoint argues that human convalescent humour is Associate in Nursing chance for bar and treatment of COVID-19 illness. convalescent sera could be accustomed treat folks with early symptoms and stop illness in those exposed. Hence, as we have a tendency to tend to unit of measurement within the within of a worldwide pandemic, we have a tendency to tend to advocate that institutions deem the emergency use of convalescent sera and begin preparations as presently as achievable. The novel coronavirus infection (COVID-19 or Coronavirus unwellness 2019) that emerged from Wuhan, Hubei province of China has unfold to several countries worldwide. Efforts are created to develop vaccines against human coronavirus (CoV) infections like MERS and SARS within the past decades. However, to date, no authorised antiviral treatment or immunizing agent exists for MERS and SARS. Most of the efforts for developing CoV vaccines and medicines target the spike supermolecule|compound protein} or S protein, the most important inducer of neutralizing antibodies. though a couple of candidates have shown effectualness in in vitro studies, not several have progressed to randomised animal or human trials, thence might have restricted use to counter COVID-19 infection. this text highlights in progress advances in coming up with vaccines and medical specialty to counter COVID-19 whereas additionally that specialize in such experiences and advances as created with earlier SARS- and MERS-CoVs, that along may modify efforts to halt this rising viral infection

Keyword : PLASMAPHERESIS, MORBILLI, GRIPPE, CORONAVIRUS, MONOCLONAL ANTIBODY