Archive : Volume - 2, Issue - 2, Month - February
1 Folic Acid and Vitamin B Complex Improves Quality of Life in Hepatitis C Infected Patients Treated with Peginterferon and Ribavirin
- Nermeen Ashoush* ,
- Manal El-Hamamsy ,
- Mona Schaalan ,
- Osama Ahmed ,
- Mohey Elmazar ,
- Osama Badary
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Abstract : Pegylated-interferon α-2a and ribavirin (PIFN/RBV), the current standard treatment for hepatitis C virus (HCV) infection in Egypt, is frequently associated with hematological adverse effects, leading to high treatment discontinuation rates. The objective of the present study is to explore the effectiveness of intervening with folic acid (F) and/or vitamin B complex (B) compared with placebo (C) in HCV-treatment Egyptian patients for the management of treatment-induced deterioration of health related quality of life (HRQOL) as well as hematological parameter. In a randomized controlled trial, one hundred and sixty subjects were randomly assigned to receive PIFN/RBV in addition to BF, B, F, or C. Blood samples were collected at different time points during 48 weeks and at 12 and 24 weeks post treatment for complete blood count and for HCV RNA real time PCR. Short form SF 36V2 questionnaire were used to assess HRQOL at various time during and post treatment. Egyptian HCV patients treated with PIFN/RBV showed deterioration of HRQOL which were correlated with deterioration in the measured hematological parameter. Supplementation with vitamin B complex plus folic acid significantly (P<0.001) decreased the deterioration observed in physical and mental health as well as complete blood count. Supplementation with either vitamin B complex or folic acid were also effective but with lower potency than their combination. BF supplementation can reduce adverse effects of PIFN/RBV therapy in chronic hepatitis C patients, which may improve patients’ HRQOL and their adherence to combination antiviral therapy.
Keyword : Hepatitis C virus, Quality of life, Folic acid, Vitamin B complex, Peginterferon, Ribavirin.
2 The Sensitivity of Gram +ve, Gram -ve Bacterial Pathogens to the Antibacterial Activity of Cultured Tissues Croton Bonpladianum Baill and their Phytochemical Studies
- Harikrishna R Saripalli* ,
- Lydia S Nandam ,
- Madan Prasad
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Abstract : The different fractions of methanolic extracts of cultured tissues of Croton bonplandianum Bail were subjected to preliminary phytochemical and in-vitro anti – bacterial studies. The different fractions revealed the presence of steroids, alkaloids, flavonoids and saponins. The antibacterial activity of the plant (Callus Cultures) different fractions of methanolic extracts was assayed by the agar plate disc diffusion technique. Three gram positive, four gram negative bacterial species were screened for the anti-bacterial investigations. The fraction II of the methanolic extract inhibited the growth of all the test bacterial species whereas fraction III and fraction IV have shown weak antibacterial activity.
Keyword : Antibacterial, Cultured tissues, Croton bonplandianum Baill and Phytochemical.
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