Abstract : Liposarcomas are common soft tissue sarcomas arising predominantly in deep soft tissue and the retroperitoneum. Inflammatory variant of Well differentiated liposarcoma (inflammatory atypical lipomatous tumor) is a rare type of low grade liposarcoma, occurring most often in the retroperitoneum. We are presenting a case of inflammatory atypical lipomatous tumor in a 54 year old male patient who presented with a soft tissue mass in the thigh. The tumor was encapsulated measuring about 8 * 6*4 cms. Histopathology revealed picture consistent with inflammatory atypical lipomatous tumor. Immunohistochemistry showed S-100 positivity in lipoblasts and Vimentin positivity in the stromal cells and was negative for Smooth muscle actin.

Keyword : Liposarcoma, Atypical lipomatous tumor, S-100

Abstract : Objectives: To determine the association of anthropometric indices with type 11 diabetes mellitus, hypertension and hyperlipidemia in Shifa Foundation Falahi Clinic, Islamabad Pakistan. Methods: This cross sectional study was conducted in Shifa Foundation Falahi Clinic, Islamabad to determine the association of obesity related indices like waist circumference (WC), waist to hip ratio (WHR), & body mass index (BMI) with type II diabetes mellitus, hypertension and hyperlipidaemia. A total of 328 patients were included. The blood pressure, fasting blood sugar (FBS) and lipid profile was also performed. The correlation and significance was determined among dependent and independent variables. Results: The mean age of the patient was 47.14 + 11.07. There was 220 (67.1%) female and 108 male (32.9%). The frequency distribution of BMI revealed that only 37 female patients (16.8%) were normal, while 27 male patients (25%) had normal BMI. The diabetes mellitus was present in 164 (50%) of the patients. Hypertension was present in 170 (51.82%) patients. The WC, WHR & BMI has a positive correlation with hypertension and statistically significant. The WC also has a positive correlation with type 11 diabetes mellitus and TG. Conclusion: The study results concluded that the anthropometric indices (WC, WHR & BMI) has a positive correlation with hypertension and statistically significant. The WC also has a positive correlation with type 11 diabetes mellitus and triglyceride (TG). Further community based studies are required to ascertain the findings of this study.

Keyword : Anthropometric indices, Diabetes mellitus, Hypertension, Blood Glucose, Lipid profile.

Abstract : Development of microbial resistance to various existing antimicrobial drugs has become a serious public health concern and the search for new classes of antimicrobial agents is a challenging task. The antimicrobial activity of the coelomic fluid (CF) obtained from Eudrilus eugeniae was investigated against five bacterial strains as well as four fungal strains using disc diffusion method to verify its claimed pharmaceutical use in the treatment of many infections. 75µl of coelomic fluid exhibited strongest antibacterial activity against Vibrio parahaemolyticus and Klebsiella pneumoniae, and antifungal activity against Candida albicans. This inhibitory effect of CF was compared with the commercial antibiotics like Ciprofloxacin and Fluconazole. For the antimicrobial screening, five species of bacterial isolate and four species of fungal isolates were selected. The bacterial cultures were used for antimicrobial testing maintained on nutrient agar slant and the fungal strains were maintained on Sabouraud dextrose agar slant at 4oC. Minimum inhibitory concentration (MIC) was determined using micro dilution broth method. The MIC results indicated that CF at a dose of 200µl for bacteria and 100µl for fungi was found to be minimum concentration to inhibit the growth of selected pathogenic bacteria and fungi. The results of the present investigation indicates that the CF of E.eugeniae has a significant capacity of antibacterial and antifungal activities, which makes them interesting for screening CF of E.eugeniae as natural product.

Keyword : Eudrilus eugeniae, Vibrio parahaemolyticus , Candida albicans and coelomic fluid, inhibition zone, antimicrobial activity

Abstract : Background: Anterior knee pain is one of the common knee injuries in dancers. It is a repetitive strain injury, with incidence of 33% of dancers. Bharatanatyam is an Indian classical dance form which has semi squatting with foot in toe out position called Aramandi. Aramandi position exerts pressure on knee, which could be a reason for anterior knee pain. Therefore screening of dancers is necessary to identify musculoskeletal problems in dancers. The main purpose of this study was to find out the correlation of toe out and anterior knee pain. Methods: 50 Bharatanatyam dancers were included in the study. Their degree of toe out, and hip external rotation was measured. They were asked to answer Kujala questionnaire and pain score was taken. Results: The correlation coefficient between VAS and Kujala was 0.0001, VAS and compensated toe out was 0.3183, and Kujala and compensated toe out was 0.5677. There was no association found between VAS and toe out, Kujala and toe out. Conclusion: Our study concluded that there is no correlation between the degree of toe out and anterior knee pain in dancers. Clinical implication: Learning Bharatanatyam does not cause knee injuries.

Keyword : Key words: Anterior Knee Pain, Bharatanatyam Dancers, Aramandi, Kujala Questionnaire, Degree of Toe Out.

Abstract : Piriformis syndrome ( PS ) is rare, presenting with symptoms and signs closely resembling L5 and S1 radiculopathy. It is a diagnosis of exclusion, requiring a high index of suspicion. Numerous clinical tests and electrodiagnosis are inconclusive. Magnetic Resonance Neurography (MRN) of Sciatic nerve yields better results but is limited by cost and lack of availability at all centres. High frequency ultrasonography (HFUS) of the Sciatic nerve overcomes the above limitations and is a reliable tool for positive diagnosis with ease of performance especially in various dynamic postures. Conventional treatment of PS is unrewarding to the physician and frustrating to the patient whereas Botulinum toxin injection into the Piriformis muscle under ultrasound guidance gives considerable relief from pain. A pilot series of five patients with clinical features of PS, confirmed by diagnostic HFUS, three of whom were injected with a fixed dose of Botulinum Toxin type A (50 units) into the Piriformis muscle on the affected side are described. Pain assessment before and three weeks after injection using the Numeric Rating Scale (NRS) demonstrated significant improvement

Keyword : Piriformis Syndrome, High Frequency Ultrasonography, Botulinum toxin