Abstract : Vitiligo is a skin disease caused by various factors with an etiology that is poorly understood. In current scenario it is not an uncommon disease as it has a history of more than 3000 years but it is often confused with leprosy. This disease effect people physically, socially, psychologically and occupationally. But with proper awareness about this disease people can easily cope up with its various effects. Doctors and mental health professionals with proper education about disease help patient in not only recovering with the disease but also in stabilizing the psychosocial effects of vitiligo. Proper support of family and friends and mental support from doctor make patients lead a normal life. Suffering caused by vitiligo can be treated by a proactive approach. Hence proper knowledge about the disease, proper treatment by doctor, proper counseling from mental health professional and proper support of family and friends can help patient in coping the psychosocial effects of vitiligo.

Keyword : Vitiligo, Psychosocial aspects, depression, coping.

Abstract : Zinc (Zn) and magnesium (Mg) have many important functions in human body. Among many contributing agents that have been proposed to take part in the pathogenesis of rheumatoid arthritis RA condition, trace elements, including Zn and Mg have also been investigated. This study aimed to evaluate the level of these elements and their correlations with duration and complications of RA. the plasma level of trace elements was estimated by the use of Atomic Absorption Spectroscopy. This cross-sectional hospital base study involved 45 rheumatoid arthritis patients compared with normal reference values of the trace elements. The analysis of the results indicated that the mean plasma levels of Zn and Mg were significantly lower when compared with their reference values, found lower levels below the lower limit of the reference value, reveals a statistical significant difference P.value (0.000, 0.000). Correlations between plasma Zn, Mg levels and complications of disease were found insignificant whereas positive correlations between the level of Zn and duration of RA disease, r=(0.4), p. value was (0.005) and between Mg level and Zn r=0.3, p. value was (0.04)patients with RA have lower levels of Zn and Mg, so the supplementation of Zn and Mg would be necessary for RA patients to correct their levels.

Keyword : RA patients, Trace elements

Abstract : Hemifacial hypertrophy is a rare condition characterized by facial asymmetry caused by marked, unilateral, localized overgrowth of one or more tissues in the affected area, including the facial muscle, bones, and teeth. The cause of this condition is unknown. These asymmetries are often noted at birth and accentuated with increasing age, especially at the time of puberty. Hemifacial hypertrophy is more likely the mild form of congenital hemihypertrophy. Here we present the case of a 25 year old male patient affected by isolated congenital hemifacial hypertrophy with significant social stigma and major aesthetic morbidity. A retrospective review of the patients’ case notes, clinical photos and three dimensional radiographic imaging was undertaken to assess condition, with particular reference to function and aesthetics. Congenital hemifacial hypertrophy can be assessed by clinical features, and tomographic imaging. Most of the cases, reported in previous literature, mentioned with traditional radiographic techniques of facial region. We characterized this condition with advanced diagnosis findings. The purpose of this case report of hemifacial hypertrophy is to supplement existing literature, and clinical knowledge with advanced diagnostic aid like three dimensional computed tomography imaging.

Keyword : congenital abnormality, congenital hypertrophy, hemifacial hypertrophy

Abstract : Baseline platelet size correlates with future residual platelet reactivity .Mean platelet volume(MPV) is a rapid and simple measure in hospital and outpatient settings. An elevated MPV is a strong independent predictor of myocardial infarction(MI)after percutaneous coronary intervention(PCI) . von Willebrand factor(vWF) is a useful clinical marker strongly correlating with the incidence of MI and prognosis after PCI. There is increased vWF release after PCI contributing to endothelial dysfunction and increased incidence of thrombosis and no reflow.To investigate the association between MPV and vWF and incidence of post-PCI MI, we assessed baseline MPV and pre and post PCI vWF antigen activity in 80 patients presented to our hospital(Mansoura specialized medical hospital) for elective PCI and then follow up of the patients was conducted for 6- months period.Statistical analysis was performed using SPSS, version 21.When the 6-months incidence of MI was stratified by baseline MPV, the incidence of myocardial infarction was significantly more frequent with increasing MPV ( 21 patients ( 72.4%) with high MPV had MI at 6 months follow up(p=.002) with mean ± SD of baseline MPV 14.97±3.76 (p=≤.001).When the 6-months incidence of MI was stratified by vWF antigen activity (pre and post PCI), the incidence of MI was significantly more frequent with increasing vWF antigen activity (20 patients (69%) out of 29 patients (100%) with normal pre PCI vWF antigen activity that demonstrated high post PCI vWF activity had MI at 6 months follow up(p=.011) with mean ± SD of vWF antigen activity 190.45±38.62 (p=≤.004).

Keyword : MPV, vWF, PCI, MI