Abstract : ABSTRACT Asymptomatic hyperuricemia is believed to be more severe and more common in patients with dual metabolic syndrome diseases (essential hypertensive disease (EHD) and type 2 diabetes mellitus (T2DM)) and comparatively less severe and less common in patients with either of these dual metabolic syndrome diseases. To determine the heterogeneity of renal pathogenicity on the background of asymptomatic hyperuricemia in the clinical course of EHD combined with T2DM using correlations between uric acid levels in the blood, systolic blood pressure levels, glycated hemoglobin, dyslipidemia, inflammatory processes, kidney damage, etc. The research included 105 patients (50 males and 55 females), aged 41-70 years, average age being (54.2±4.0) years. Patients were divided into 3 groups: Group I (GI) consisted of 25 patients with treatment-compensated EHD, 1-2 degree, stage II; Group ІІ (GII) was made up of 25 patients with subcompensated T2DM (glycated hemoglobin (HbA1C) - from 7.0 to 11.0%); Group III (GIII) had 55 patients with EHD, 1-2 degree, stage ІІ combined with subcompensated T2DM. Control group consisted of 15 practically healthy volunteers, 10 (66.7%) females and 5 (33.3%) males, aged (54.6±4.2) years. Groups were randomized according to age, sex, BMI, duration of EHD and T2DM. In addition to general clinical examination conducted; blood levels of uric acid (UA), lipids, tumour necrosis factor alpha (TNF-α), high-sensitivity C-reactive protein (hs-CRP) were determined. Urine levels of neutrophil gelatinase-associated lipocalin (NGAL) was also determined using immuno-fermentation methods. Asymptomatic hyperuricemia characterized by an increase in blood uric acid level of more than 410 μmol/l was observed in 34.6% of GI patients, in 21.8% of GII patients and most commonly in 55.7% of GIII patients with EHD combined with T2DM. Correlations between blood uric acid level with albuminuria was found (r=+0.42; p<0.05); with decrease in GFR (r=-0.51; p<0.05); with increase in NGAL level in urine (r=+0.56; p<0.05), which indicate an adverse effect of asymptomatic hyperuricemia on the functional state of the kidneys in patients with EHD and concomitant T2DM. Positive correlative relationships exist between asymptomatic hyperuricemia, increased albuminuria and a decrease in GFR, dyslipidemia, SBP, HbA1C, inflammatory processes and kidney damage, which indicate the heterogeneity of renal pathogenicity in patients with EHD combined with T2DM and a higher risk of cardiovascular disease in such patients. Keywords: Heterogeneity, renal pathogenicity, asymptomatic hyperuricemia, metabolic syndrome diseases, essential hypertensive disease, type 2 diabetes mellitus

Keyword : Heterogeneity, renal pathogenicity, asymptomatic hyperuricemia, metabolic syndrome diseases, essential hypertensive disease, type 2 diabetes mellitus

Abstract : Colpocephaly is a rare congenital brain malformation resulting in disproportionately large occipital horns of lateral ventricles compared to frontal ones resulting from corpus callosal and other white matter developmental arrest. Colpocephaly can be associated with partial or complete agenesis of the corpus callosum, chiari malformations, lissencephaly, and microcephaly. Colpocephaly can present with headache, seizure disorder, visual impairment, movement abnormalities and muscle spasms or can even be asymptomatic. We report a case of a 21-year old male with colpocephaly presenting as a status epilepticus (SE) as an initial symptom along with incidental cardiac anomaly OS ASD (Ostium secundum atrial septal defect) found on routine screening.

Keyword : Colpocephaly, Status Epilepticus, Ostium Secondum Atrial Septal Defect, Ventriculomegaly, Corpus callosal agenesis

Abstract : Aim: To evaluate patient satisfaction of electrically welded and cast metal frameworks in the screw-retained implant-supported prosthesis. Methodology: 12 completely edentulous patients received complete dentures; six implants were inserted in maxillary arch. Second-stage surgery was performed following the usual protocol. Shaping abutments were connected to the implants on one side of the arch, and titanium wire was bent and attached to the implants by intraoral electric welding. On the other side, the cast metal framework was performed. Then both cast and welded frameworks were picked up in the complete maxillary denture after their modification. Patient satisfaction was assessed within 2 weeks, 4 months, 6 months, and 12 months after prosthesis delivery. Results: Throughout the intervals, there was a significant increase in patient satisfaction with the prosthesis, but there was no significant difference between the two groups. Conclusions: The intra-oral electric welding is considered a promising treatment option compared to the conventional cast framework regarding patient satisfaction when used under screw-retained implant-supported prosthesis.

Keyword : complete denture, electric welded framework, screw retained prosthesis.