Abstract : Lumefantrine is a antimalarial drug which is widely used in malaria endemic areas. For anti-malaria therapy Lumefantrine is used in combination with Artemether under the brand name of co-artem. Lumefantrine have an endoperoxide bridge, which interferes with haeme polymerization critical detoxifying pathway for the malaria parasite and also inhibiting in the nucleic acid and protein synthesis within the parasite as a secondary action. The Lumefantrine-Artemether combination is the first line therapy recommended by Brazilian Health Ministry to the falciparum malaria treatment (Brasil, 2006) now a days. This article examines published analytical methods reported so far in the literature for the determination of Lumefantrine in biological samples and pharmaceutical formulations; they include various techniques like spectrophotometer, high pressure liquid chromatography, liquid chromatography-electrospray ionization tandem mass spectrometry and high-performance thin layer chromatography.

Keyword : Lumefantrine, Analytical methods, Anti malarial

Abstract : Polycystic ovarian syndrome (PCOS) is associated with dyslipidaemia and may render the affected women “at risk” of developing cardiovascular disease. Objective of this study was to evaluate lipid parameters in Sudanese Patients with Polycystic Ovary Syndrome. The study was case control hospital based carried, out on 32 diagnosed PCOS subjects aged (18-35 years) and 32 age-matched healthy women. Blood samples were collected in a fasting state and lipid parameters were estimated by Biosystem Kits using Spectrophotometer. The mean ± standard deviation of total cholesterol, triglycerides, LDL, VLDL, HDL respectively in cases were (194±36.3, 95.8±29.0, 128.4±32.1, 19.1±5.8, 47.1±14.1). while the mean and standard deviation of total cholesterol, triglycerides, LDL, VLDL, HDL respectively in control were (166.22±16.7, 86.1±12.6, 89.9±21.2, 17.22±2.53, 59.5±12.3). There were significant elevation in most lipid profile. The study concluded that, most lipid profile were significantly increased except triglycerides and VLDL.

Keyword : Polycystic ovarian syndrome, lipid profile, Sudanese.

Abstract : Transdermal gel has gained more and more importance because the gel based formulations are better percutaneously absorbed than other topical dosage forms. Hypertension is defined by an elevation of the systolic or diastolic threshold or both. Atenolol, a class III molecule is a selective cardio-vascular β-blocker, which block the synthesis of Adenylate Cyclase there by prevents the formation of intra cellular messenger, cyclic AMP responsible for the activation of various protein kinases responsible for phosphorylation. The present work involve in the formulation of Atenolol Transdermal gels by dispersion method with different ratios of polymers for the sustained release of the drug through Stratum Corneum using Di-Methyl Sulphoxide, as penetration enhancer for the treatment of hypertension. All the formulations were evaluated for physico-chemical parameters and all the values were obtained within the limits. The in-vitro diffusion studies were carried out against dialysis membrane and ex-vivo permeation studies using albino rat abdominal skin by Franz diffusion cells. On hydration, osmotic pressure breaks & drug release follow zero order. Among fifteen formulations, In-vitro % Drug Release values of the optimized formulations were figured to be 98.22, 96.42 & 94.62 for F2, F11 & F13 respectively. The drug permeated/cm2 through skin was also determined by flux value for optimized formulations F2, F11 and F13 was 0.073 gmH-1cm-2, 0.069 gmH-1cm-2 and 0.082 gmH-1cm-2 respectively.

Keyword : Franz diffusion cell, Di-Methyl Sulphoxide, Dialysis Membrane, Albino Rats