Author Name : Julius Olugbenga Soyinka
1 Insights and Current Perspectives on Pharmacogenomics of Antimalarial Drugs
- Julius Olugbenga Soyinka* ,
- Charles Okeke Nnadi ,
- Sharon Iyobor Igbinoba ,
- Cyprian Ogbona Onyeji
- Abstract
- Show Article
- Download : 182
- Google Citation
- Journal DOI : 10.5281/zenodo.10002775
- Certificate
Abstract : Abstract
Malaria constitutes a major public health concern in tropical and other malaria-endemic regions. Genetic and non-genetic factors are known to influence the pharmacokinetics and/or pharmacodynamics of drugs including antimalarial drugs resulting in variability in drug responses. This article aimed to update perspectives on pharmacogenomics and also provide an updated appraisal of genetic variability in drug-metabolizing enzymes which alter the disposition of antimalarial drugs causing variations in treatment outcomes. Important literature databases such as Elsevier, IEEExplore, Pubmed, Scopus, Web of Science, Google Scholar, ProQuest, ScienceDirect, and BioMed Central were selected based on the quality, extant content, and broad area of the discipline. The specific keywords related to the study were identified and used for the study purposely to identify related works. Advances in genetic research have facilitated the identification of Single Nucleotide Polymorphisms (SNPs) that alter the activity of drug-metabolizing enzymes that metabolize most antimalarial drugs. There is an association between isoforms of CYP450 gene variants and the efficacy of some antimalarial drugs, and this may be applied to the optimization of malarial therapy. Although identification of cytochrome P450 (CYP450) gene variants can be used for personalization of malaria treatment, several challenges are encountered in this process but some resources provide education and guidelines on how to use the pharmacogenetic results of specific drugs.
Keyword : Keywords: Antimalarial drugs; Cytochrome P450; Gene Variants; Pharmacogenomics
Login
Loading....
Author Guideline
Copyright Form
News Update
Archive List
- Volume-11
- Volume-10
- January 2023 Issue 1
- January 2023 Issue 1
- February 2023 Issue 2
- March 2023 Issue 3
- March 2023 Issue 3
- April 2023 Issue 4
- April 2023 Issue 4
- May 2023 Issue 5
- May 2023 Issue 5
- May 2023 Issue 5
- June 2023 Issue 6
- June 2023 Issue 6
- July 2023 Issue 7
- July 2023 Issue 7
- August 2023 Issue 8
- August 2023 Issue 8
- September 2023 Issue 9
- October 2023 Issue 10
- November 2023 Issue 11
- December 2023 Issue 12
- Volume-9
- January 2022 Issue 1
- February 2022 Issue 2
- March 2022 Issue 3
- April 2022 Issue 4
- May 2022 Issue 5
- June 2022 Issue 6
- July 2022 Issue 7
- July 2022 Issue 7
- July 2022 Issue 7
- July 2022 Issue 7
- August 2022 Issue 8
- September 2022 Issue 9
- October 2022 Issue 10
- October 2022 Issue 10
- November 2022 Issue 11
- November 2022 Issue 11
- November 2022 Issue 11
- December 2022 Issue 12
- Volume-8
- January 2021 Issue 1
- February 2021 Issue 2
- February 2021 Issue 2
- March 2021 Issue 3
- April 2021 Issue 4
- May 2021 Issue 5
- June 2021 Issue 6
- June 2021 Issue 6
- June 2021 Issue 6
- July 2021 Issue 7
- August 2021 Issue 8
- September 2021 Issue 9
- October 2021 Issue 10
- November 2021 Issue 11
- December 2021 Issue 12
- Volume-7
- January 2020 Issue 1
- January 2020 Issue 1
- February 2020 Issue 2
- March 2020 Issue 3
- March 2020 Issue 3
- March 2020 Issue 3
- April 2020 Issue 4
- April 2020 Issue 4
- May 2020 Issue 5
- May 2020 Issue 5
- May 2020 Issue 5
- June 2020 Issue 6
- June 2020 Issue 6
- June 2020 Issue 6
- July 2020 Issue 7
- August 2020 Issue 8
- September 2020 Issue 9
- October 2020 Issue 10
- November 2020 Issue 11
- December 2020 Issue 12
- December 2020 Issue 12
- Volume-6
- January 2019 Issue 1
- February 2019 Issue 2
- March 2019 Issue 3
- April 2019 Issue 4
- April 2019 Issue 4
- May 2019 Issue 5
- May 2019 Issue 5
- June 2019 Issue 6
- June 2019 Issue 6
- July 2019 Issue 7
- July 2019 Issue 7
- August 2019 Issue 8
- September 2019 Issue 9
- September 2019 Issue 9
- September 2019 Issue 9
- October 2019 Issue 10
- November 2019 Issue 11
- November 2019 Issue 11
- November 2019 Issue 11
- December 2019 Issue 12
- Volume-5
- January 2018 Issue 1
- January 2018 Issue 1
- February 2018 Issue 2
- March 2018 Issue 3
- April 2018 Issue 4
- May 2018 Issue 5
- June 2018 Issue 6
- July 2018 Issue 7
- August 2018 Issue 8
- September 2018 Issue 9
- September 2018 Issue 9
- October 2018 Issue 10
- October 2018 Issue 10
- November 2018 Issue 11
- December 2018 Issue 12
- December 2018 Issue 12
- Volume-4
- January 2017 Issue 1
- February 2017 Issue 2
- February 2017 Issue 2
- March 2017 Issue 3
- April 2017 Issue 4
- April 2017 Issue 4
- May 2017 Issue 5
- June 2017 Issue 6
- June 2017 Issue 6
- June 2017 Issue 6
- June 2017 Issue 6
- July 2017 Issue 7
- August 2017 Issue 8
- August 2017 Issue 8
- September 2017 Issue 9
- October 2017 Issue 10
- November 2017 Issue 11
- December 2017 Issue 12
- December 2017 Issue 12
- December 2017 Issue 12
- Volume-3
- January 2016 Issue 1
- February 2016 Issue 2
- March 2016 Issue 3
- April 2016 Issue 4
- May 2016 Issue 5
- June 2016 Issue 6
- June 2016 Issue 6
- July 2016 Issue 7
- July 2016 Issue 7
- July 2016 Issue 7
- August 2016 Issue 8
- September 2016 Issue 9
- October 2016 Issue 10
- October 2016 Issue 10
- November 2016 Issue 11
- November 2016 Issue 11
- December 2016 Issue 12
- Volume-2
- Volume-1
Statastics
Download of Articles
115,504