Archive : Volume - 4, Issue - 10, Month - October
1 Diagnostic Sensitivity of Anti-cyclic Citrullinated Peptide ACCP2 and Rheumatoid Factor Isotypes RFs in Sudanese Rheumatoid Arthritis RA Patients.
- AbdElkarim A Abdrabo* ,
- Salih A Elmahdi ,
- AbdallaEltoum Ali ,
- Musa A M Nur ,
- Elnoor M Elagib ,
- Abdelrahim O Mohamed
- Abstract
- Show Article
- Download : 179
- Certificate
Abstract : The early diagnosis is essential, as it has been observed that progression occurs within 2 years of disease onset.. An aggressive intervention with new and effective biological treatments can alter the course of the disease, prevent joint destruction, lengthen life, and improve function . RA is known to be associated with broad range or the presence of a large number of autoantibodies The present study was designed as a case-control study, carried out in the National Ribat University Hospital, in Khartoum State, Sudan. The aim of this study was to assess the diagnostic value of RA serological markers. The study group composed of 88 patients with RA; all patients had fulfilled the criteria of the American College of Rheumatology (ACR) (5), whereas control group composed of 53 healthy individuals. Blood samples were collected from the study population in order to determine RF-isotypes namely (RF-IgM, RF-IgA), and ACCP2. RF-isotypes and ACCP2 were measured quantitatively using a Sandwich Enzyme–Linked Immunosorbant Assay ELISA (Euroimmune, Germany). displayed that 56.8% of the study group had positive RF-IgM, where it was 22.6% in control group. RF-IgA showed positive reaction in 47.7% and 30.2% of study group and control group, respectively Both RF-isotypes were found to be positive in 33(37.5%) and 6(11.3%) of study group and control group respectively. The ACCP2 was found positive in 52(59.1%) of study group and in 3(5.7%) of control group (table 2). The mean value of ACCP2 in RA patients was statistically significant than that of control group (p.value =0.000). Sensitivity for RA was highest for ACCP2 59%, followed by RF-IgM 56.82%. Utility of two combined RF-isotypes autoantibodies sensitivity for RA was 69(78.4%) and will be 90.9% when ACCP2 was enrolled with the 2 RF-isotypes. In this study 11(12.5%) patients were RF-isotypes negative and positive for ACCP2. Correlation between ACCP2 & RF-IgM was 0.386 and was 0.255 between ACCP2 and RF-IgA and there was no such correlations with the controls. This study showing that the ACCP2 had slightly better sensitivity than RFs among RA patients, and the diagnostic sensitivity of RA increased when ACCP2 was added in the panel along with RF-isotypes.
Keyword : Rheumatoid arthritis, Auto-antibodies of ACCP2 and RF-IgM plus RF-IgA, Sudan
Login
Loading....
Author Guideline
Copyright Form
News Update
Archive List
- Volume-11
- Volume-10
- January 2023 Issue 1
- January 2023 Issue 1
- February 2023 Issue 2
- March 2023 Issue 3
- March 2023 Issue 3
- April 2023 Issue 4
- April 2023 Issue 4
- May 2023 Issue 5
- May 2023 Issue 5
- May 2023 Issue 5
- June 2023 Issue 6
- June 2023 Issue 6
- July 2023 Issue 7
- July 2023 Issue 7
- August 2023 Issue 8
- August 2023 Issue 8
- September 2023 Issue 9
- October 2023 Issue 10
- November 2023 Issue 11
- December 2023 Issue 12
- Volume-9
- January 2022 Issue 1
- February 2022 Issue 2
- March 2022 Issue 3
- April 2022 Issue 4
- May 2022 Issue 5
- June 2022 Issue 6
- July 2022 Issue 7
- July 2022 Issue 7
- July 2022 Issue 7
- July 2022 Issue 7
- August 2022 Issue 8
- September 2022 Issue 9
- October 2022 Issue 10
- October 2022 Issue 10
- November 2022 Issue 11
- November 2022 Issue 11
- November 2022 Issue 11
- December 2022 Issue 12
- Volume-8
- January 2021 Issue 1
- February 2021 Issue 2
- February 2021 Issue 2
- March 2021 Issue 3
- April 2021 Issue 4
- May 2021 Issue 5
- June 2021 Issue 6
- June 2021 Issue 6
- June 2021 Issue 6
- July 2021 Issue 7
- August 2021 Issue 8
- September 2021 Issue 9
- October 2021 Issue 10
- November 2021 Issue 11
- December 2021 Issue 12
- Volume-7
- January 2020 Issue 1
- January 2020 Issue 1
- February 2020 Issue 2
- March 2020 Issue 3
- March 2020 Issue 3
- March 2020 Issue 3
- April 2020 Issue 4
- April 2020 Issue 4
- May 2020 Issue 5
- May 2020 Issue 5
- May 2020 Issue 5
- June 2020 Issue 6
- June 2020 Issue 6
- June 2020 Issue 6
- July 2020 Issue 7
- August 2020 Issue 8
- September 2020 Issue 9
- October 2020 Issue 10
- November 2020 Issue 11
- December 2020 Issue 12
- December 2020 Issue 12
- Volume-6
- January 2019 Issue 1
- February 2019 Issue 2
- March 2019 Issue 3
- April 2019 Issue 4
- April 2019 Issue 4
- May 2019 Issue 5
- May 2019 Issue 5
- June 2019 Issue 6
- June 2019 Issue 6
- July 2019 Issue 7
- July 2019 Issue 7
- August 2019 Issue 8
- September 2019 Issue 9
- September 2019 Issue 9
- September 2019 Issue 9
- October 2019 Issue 10
- November 2019 Issue 11
- November 2019 Issue 11
- November 2019 Issue 11
- December 2019 Issue 12
- Volume-5
- January 2018 Issue 1
- January 2018 Issue 1
- February 2018 Issue 2
- March 2018 Issue 3
- April 2018 Issue 4
- May 2018 Issue 5
- June 2018 Issue 6
- July 2018 Issue 7
- August 2018 Issue 8
- September 2018 Issue 9
- September 2018 Issue 9
- October 2018 Issue 10
- October 2018 Issue 10
- November 2018 Issue 11
- December 2018 Issue 12
- December 2018 Issue 12
- Volume-4
- January 2017 Issue 1
- February 2017 Issue 2
- February 2017 Issue 2
- March 2017 Issue 3
- April 2017 Issue 4
- April 2017 Issue 4
- May 2017 Issue 5
- June 2017 Issue 6
- June 2017 Issue 6
- June 2017 Issue 6
- June 2017 Issue 6
- July 2017 Issue 7
- August 2017 Issue 8
- August 2017 Issue 8
- September 2017 Issue 9
- October 2017 Issue 10
- November 2017 Issue 11
- December 2017 Issue 12
- December 2017 Issue 12
- December 2017 Issue 12
- Volume-3
- January 2016 Issue 1
- February 2016 Issue 2
- March 2016 Issue 3
- April 2016 Issue 4
- May 2016 Issue 5
- June 2016 Issue 6
- June 2016 Issue 6
- July 2016 Issue 7
- July 2016 Issue 7
- July 2016 Issue 7
- August 2016 Issue 8
- September 2016 Issue 9
- October 2016 Issue 10
- October 2016 Issue 10
- November 2016 Issue 11
- November 2016 Issue 11
- December 2016 Issue 12
- Volume-2
- Volume-1
Statastics
Download of Articles
115,505