Suhair A Ahmed

Thyroid hormones regulate the metabolisms of all cells including hepatocytes, and hence, modulate hepatic function .Thyroid disorders often accompany abnormal serum enzyme levels and disturbances in liver functions, this study aim to assess relationship between serum enzymes and liver functions in thyroid disorders. 40 cases of hyperthyroidism and 40 controls were induced in this study by convenience sampling. Their liver enzyme profile for aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) were determined and analyzed for correlation. Three variables were measured for all cases and controls, plasma level activity of liver specific enzymes ALT, AST and ALP. The mean values between cases and controls showed a significant increase in ALP and ALT and no significant difference was shown in AST. Also a correlation was found between age, gender and ALP among cases while no correlation was found in AST and ALT.

Hypertension is believed to have a wide range of effects on body's physiology with a controversial data on the association between hypertension and elevation of liver enzymes. Liver enzymes such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyltransferase (GGT) are considered as markers of liver function. To investigate the proposed association of hypertension with liver enzymes. fifty-eight hypertensive patients were enrolled in this study with a mean age of 28-76 and another age-matched group of 42 individuals selected as a control group, demographic data were collected in a predesigned form, then the liver enzymes were measured for the patients as well as the individuals of the control group. Statistical analysis was performed using SPSS, version 16. The means of plasma AST, ALT, ALP and GGT levels among patients were 20.79, 12.69, 81.72, and 20.48, respectively and among control group were 18.45, 9.53, 81.14 and 16.28 respectively, in spite of this obvious variations in liver enzymes among hypertensive patients when compared to the controls, this variation was found to be statistically insignificant. The study also showed that the plasma levels of AST (r=0.05, P value=0.089). and ALT (r=0.004, P value=0.972),ALP (r=0 .128,P value=0.214) were negatively correlated with BMI while the GGT(r=0.343, P value=0.000)was positively correlated with BM. The levels of liver enzymes in hypertensive patients were not significantly elevated compared to control group. While there is a correlation between BMI and plasma enzymes GGT. Levels of transaminases AST and ALT revealed significant association with the duration of hypertension.

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women in the reproductive age. It is characterized by an ovulation manifested as oligomenorrhea or amenorrhea, elevated levels of androgens and luteinizing hormone (LH), and polycystic ovaries by ultrasound. PCOS also encompasses a broad spectrum of clinical, hormonal and ultrasonographic characteristics.The study was aimed to compare serum AMH levels between PCOS and normal women; and to investigate the relationship between AMH and testosterone.An analytical case control study implemented in Dr. Alser Abulehassan Center for Infertility, Khartoum. A number of 50 women with PCOS and a number of 30 healthy women were recruited for the study. Medical records were examined for patients who sought fertility consultation or treatment during the period from April 2015 till June 2015. The study protocol was approved by the Medical Ethical Committee of Alneelain University. AMH and Testosterone were significantly higher in the PCOS women in comparison to normal women. The AMH was positively correlated to Testosterone (r=.691, p<0.01), and negative correlation with body excessive hair (r= - 426, p< 0.05). Also negative correlation was found between infertility and excessive body hair (r= - 3.17, p< 0.05), while no correlation was found between AMH and women age and weight. Higher serum AMH and testosterone levels in PCOS women than in healthy women; and significant positive correlations between AMH and testosterone and in the PCOS women exclusively. AMH has been proposed as a marker of PCOS and as suggested to be useful initial diagnostic test for PCOS.