PCOS

Background: Polycystic ovary syndrome (PCOS) is a common complex; heterogeneous endocrine disorder characterized by irregular menses, hyperandrogenism, and infertility. Aims: To study the outcome of laparoscopic ovarian drilling in clinical presentations in form of cycle pattern, acne & Hirsiutism in addition to their conception among infertile Sudanese patients with PCOS.Methods: A hospital based cohort study which was conducted in two hospitals in Khartoum state, Sudan; Omdurman Maternity Hospital & Saad Abu Elela hospital from January to December 2018.Targeted 145 infertile patients diagnosed as PCOS based on Rotter-Dam criteria 2003 definition and who did not conceive after diet, lifestyle and clomiphene; underwent laparoscopic ovarian drilling (LOD).data was collected using semi-structured questionnaires before the drilling ,then the patient was followed in 3 month time concerning the Clinical Presentations, and Conception Results: 65(44.8%) out of 145 infertile patients age was between 21-30 yrs, 67(46.2%) were obese with BMI >30; 90 (62.1%) of participants had irregular cycle., Hirsiutism was seen in 55 (37.9%) and acne was observed in 89 (61.4%). After laparoscopic drilling, 55.2% of patients had normal cycle pattern, amenorrhea & menorrhagia dropped to 3.5% & 11.7% respectively. About 46.2% had normal weight .Acne was seen in 32(22.2%) & Hirsiutism present in 42(19.3%) and 43 (29.6%) get pregnancy, BMI, acne & Hirsiutism before and after LOD were correlated using Chi square P value was 0.001, 0.002, and 0.007 respectively which was significant at (P ≥0.05). Conclusion: The path physiology of PCOS improves, after LOD concerning clinical presentations, & conception. Management of PCOS is essential to address patient concerns, prevent metabolic, & endocrine complications.

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women in the reproductive age. It is characterized by an ovulation manifested as oligomenorrhea or amenorrhea, elevated levels of androgens and luteinizing hormone (LH), and polycystic ovaries by ultrasound. PCOS also encompasses a broad spectrum of clinical, hormonal and ultrasonographic characteristics.The study was aimed to compare serum AMH levels between PCOS and normal women; and to investigate the relationship between AMH and testosterone.An analytical case control study implemented in Dr. Alser Abulehassan Center for Infertility, Khartoum. A number of 50 women with PCOS and a number of 30 healthy women were recruited for the study. Medical records were examined for patients who sought fertility consultation or treatment during the period from April 2015 till June 2015. The study protocol was approved by the Medical Ethical Committee of Alneelain University. AMH and Testosterone were significantly higher in the PCOS women in comparison to normal women. The AMH was positively correlated to Testosterone (r=.691, p<0.01), and negative correlation with body excessive hair (r= - 426, p< 0.05). Also negative correlation was found between infertility and excessive body hair (r= - 3.17, p< 0.05), while no correlation was found between AMH and women age and weight. Higher serum AMH and testosterone levels in PCOS women than in healthy women; and significant positive correlations between AMH and testosterone and in the PCOS women exclusively. AMH has been proposed as a marker of PCOS and as suggested to be useful initial diagnostic test for PCOS.