Mahmudul Haque

Childhood Obesity is a major cause of mortality and morbidity around the world. Its prevalence is increasing dramatically regardless of age and geographical variation becomes a serious public health problem. A cross sectional comparative study was conducted in the Department of Biochemistry, Chittagong Medical College, Bangladesh during the period from July 2013 to June 2014. The aim of the study was to evaluate the relationship between serum lipid profile with childhood overweight and obesity. Total 100 subjects were included in this study. Among them 50 were Case (Group A) whose BMI was ≥85th percentile and 50 were Control (Group B) whose BMI (Body Mass Index) was >5th percentile to 84th percentile. Serum Total cholesterol, LDL-C (Low Density Lipoprotein Cholesterol), HDL-C(High Density Lipoprotein Cholesterol) and TG(Triglyceride) were measured in all samples in fasting state. The test statistics used to analyze the data were descriptive statistics, Chi-square (X2) test, Student’s t-Test and Correlation co-efficient. The average BMI of cases were 25.91±3.67 kg/m2 and controls were 19.12±2.10kg/m2. The mean weight of cases were 58.30±12.70 kg and controls were 46.08±8.19kg.The mean serum LDL in cases was 104.28±19.70 mg/dl and control was 77.22±19.14 mg/dl.. The mean serum TG in cases was 120.80±33.20mg/dl and control was 83.78±20.33mg/dl. In cases the mean serum HDL-C was 43.40±4.01 mg/dl and control was 45.56±4.48 mg/dl respectively. Pearson’s correlation coefficient(r) showed that there was a positive correlation between BMI and total cholesterol(r=+0.535, p=<0.005) BMI and LDL-C(r=+0.520, p=<0.005), BMI and TG (r=+0.550, p=<0.05) and negative correlation between BMI and HDL-C(r= -0.27, p=<0.005)

Diabetes mellitus (DM) is a metabolic disorder of multiple aetiology characterized by chronic hyperglycemia with disturbances of carbohydrate,fat and protein metabolism resulting from defects in insulin secretion, insulin action,or both. The chronic hyperglycemia of diabetes is associated with long-term damage, dysfunction and failure of different organs, especially the eyes, kidneys, nerves, heart, and blood vessels. A case-control study was carried out in Chittagong Medical College, Chittagong, Bangladesh during the period of January 2012 to December 2012. The samples were collected from the department of Medicine, Chittagong Medical College Hospital. The age limits of the patients were from 30-70 years. The data were collected by a structured questionnaire including age, sex, blood pressure, total cholesterol. Total numbers of patients were 90 of which 50 were considered as cases (All type-II diabetic patients having (i) age 30-70 years (ii) Fasting blood sugar ≥ 7 mmol /L. (iii) Random blood sugar ≥11.1 mmol/L. (iv) 2 hrs. after oral glucose load is ≥ 11.1mmol/L and 40 controls (non-diabetic, age 30-70 years, absence of renal, liver and cardiovascular diseases). The study was designed to observe the postprandial triglyceride level in type-II diabetic patients. The mean fasting triglyceride level of cases was 210.70 (±19.5) and the 2hrs, 4hrs and 6hrs after test meals were 238.9 (±22.75), 260.5 (±15.36), and 260.32 (±5.94) respectively. At the same time the mean fasting triglyceride of the control was 173.75 (±19.86) and the corresponding mean of the control were 189.75 (±15.23), 174.38 (±16.49) and 173.88 (±15.79) mg/dl respectively. The fasting and postprandial (2hrs, 4hrs and 6hrs) triglyceride levels were significantly higher than that of corresponding control. There are also significant differences of triglyceride level in fasting and 2hrs, 4hrs and 6hrs after test meal among the cases which indicated that the triglyceride levels remained eleva