Virtual Screening Based Synthesis of Analogs of Quercetin As Insulin Receptor Activators And In-Vivo Comparative Evaluation For Anti-Diabetic Activity

ABSTRACT Literature reveals that quercetin shows hypoglycaemic active by more than one way. In present work virtual docking study of quercetinand its probable analogs was carried out on insulin receptor PDB ID:1IR3by using biopredicta module of Vlife MDS 4.3.In results of virtual screening it was found that 2-(3, 4 dihydroxy phenyl)-3,5,7-trihydroxy-4H chromen-4-one(quercetin) and its probable analogs 3-hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one (analog 1), 3,7-dihydroxy-2-(3-methoxyphenyl)-4H-chromen-4-one(analog5)and 3-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4- one(analog7) showed promising results and hence were synthesized. The results of in- vivo screening confirm the results of virtual screening as analogs 1, 5 and 7 have shown better activity hypoglycamic activity than quercetin. Keywords: Quercetine, synthetic analogs, Diabetes mellitus, Virtual screening