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British Journal of Medical and Health Research

📢 Latest Update: Call for Papers: Special Issue on Medical and Health Research – Submit to British Journal (BJMHR) by March 31, 2026

📢 Latest Update: Call for Papers: Special Issue on Medical and Health Research – Submit to British Journal (BJMHR) by March 31, 2026

Volume 6, Issue 3 - 2019 (March 2019 Issue 3)

Volume 6 Issue 3 Cover

Issue Details:

Volume 6 Issue 3
Published:Invalid Date

Editorial: March 2019 Issue 3

Welcome to the 2019 issue of British Journal of Medical and Health Research. This issue showcases the remarkable breadth and depth of contemporary research across multiple disciplines. From cutting-edge applications of machine learning in climate science to the revolutionary potential of quantum computing in drug discovery, our featured articles demonstrate the power of interdisciplinary collaboration in addressing global challenges.

We are particularly excited to present research that bridges traditional academic boundaries, reflecting our journal's commitment to fostering innovation through cross-disciplinary dialogue. The integration of artificial intelligence with environmental science, the application of blockchain technology to supply chain management, and the convergence of urban planning with smart city technologies exemplify the transformative potential of collaborative research.

As we continue to navigate an era of rapid technological advancement and global challenges, the research presented in this issue offers both insights and solutions that will shape our future. We thank our authors, reviewers, and editorial board members for their continued dedication to advancing knowledge and promoting scientific excellence.

Dr Hemangi J Patel
Editor-in-Chief
British Journal of Medical and Health Research

Articles in This Issue

Showing 7 of 7 articles
Research PaperID: BJMHR0603001

Association Between Childhood Seizures and Speech and Language Impairment

Bharati Mehta, Anu . Vyas, Bharti . Bhandari, Manish . Parakh

ABSTRACT A large group of children develop language impairment where an obvious cause for the same such as impaired hearing, mental retardation, cleft lip/palate, gross neurological or neuromuscular abnormalities affecting the speech apparatus, and autism cannot be found. This group is labeled as specific language impairment (SLI) The study aimed to assess the association between specific language impairment and childhood seizures. Out of 94 patients of SLI, about one fifth 19 (20.21%) had history suggestive of seizures, of which 15 (78.9 %) were males and 4 (21.05%) females. Majority (57.9%) of patients had generalized tonic-clonic seizures (n=11), in 21% of patients the picture was that of myoclonic seizures (n=4), in another 15.8% (n=3) history of status epilepticus was documented. Associated risk factors of SLI such as family history of seizures, prenatal, perinatal and postnatal factors were also studied. The current study observed a very high association of seizures in this cohort of children with specific language impairment. Since SLI has a multifactorial etiology, seizures per se could not cause these disorders. Prenatal and perinatal insults, along with other risk factors may account for development of SLI. However, presence of seizures, particularly in infancy should be considered a warning signal to screen such children for development of specific language impairment. Keywords: EEG, Seizures, Specific language impairment.

EEGSeizuresSpecific language impairment.
33,547 views
10,148 downloads

Contributors:

 Bharati Mehta
,
 Anu . Vyas
,
 Bharti . Bhandari
,
 Manish . Parakh
Research PaperID: BJMHR0603002

Red cabbage and broccoli (Brassica oleracea) extracts inhibits cell proliferation by inducing apoptosis in colorectal cell lines

Karim Samy El-Said, Karim Samy El-Said, Maisa Mohamed Abd Elhamid, El-Refaie Sobhy Kenawy

Plants-derived chemical constituents have been potentially used in cancers therapy, which are safer than chemotherapy. Apoptosis is a cellular process of defined programmed cell death that is of tremendous interest to study and treat cancer. In the present study, the antioxidants activities of red cabbage leaves and broccoli florets (Brassica vegetables) extracts and their apoptotic effects on colorectal cancer cell lines (CaCO2) were investigated. Antioxidants properties of the aqueous methanolic extracts were addressed through determining total phenolics, flavonoids, total antioxidant capacities and DPPH scavenging activities. Then, anticancer properties were assessed by determining the inhibitory concentrations that kill 50% of CaCO2 using MTT assay. To investigate the apoptotic effects of the extracts, gene expression analysis using real time polymerase chain reaction (RT-PCR) of Bax, caspase 3 and Bcl2 genes was done. The results showed that red cabbage and broccoli extracts exhibited powerful antioxidant activities. Furthermore, these extracts induce apoptosis in CaCO2 cells by upregulating Bax and caspase 3 and downregulating Bcl2 genes. In conclusion, red cabbage extract showed strong antioxidant activities more than broccoli extract, while broccoli inhibit proliferation of colon cancer cells by promoting apoptosis more than red cabbage done. Cruciferous vegetables contain important substances targeting apoptosis in CaCO2 cell lines that can significantly inhibit colon cancer growth.

Red cabbageBroccoliColorectal cell linesAntioxidantsAnticancerApoptosis
33,576 views
10,179 downloads

Contributors:

 Karim Samy El-Said
,
 Karim Samy El-Said
,
 Maisa Mohamed Abd Elhamid
,
 El-Refaie Sobhy Kenawy
Research PaperID: BJMHR0603003

Waist circumference is a Useful Indicator for Non-alcoholic Fatty Liver Disease Patients Visiting Gastro and Liver Care Hospital in Ongole City, Prakasam District, Andhra Pradesh

DEVARKONDA VENKATESWARLU, B. T. Rao

ABSTRACT NAFLD is commonly develops among 40-50 years and even with non consumption of alcohol patient with any component of metabolic syndrome may develop hepatic steatosis. Waist circumference is the cost effective clinical tool to assess the obesity and NAFLD. Cross sectional study was conducted in Vijaya Sree Hospitals Gastro and Liver care centre; in Ongole city, Prakasam District of Andhra Pradesh. Ultrasonographically confirmed fatty liver cases visiting to hospital for the purpose of gastrointestinal and liver problems were enrolled in the study from January 2016 to May 2016. Pre tested, pre structured, validated questionnaire was used to get the information from the patients: Continuous variables were presented with descriptive analysis like mean ± standard deviation (SD). Pearson's correlation analysis was carried out between waist circumference and waist to hip ratio with body mass index. Among the total 184 study participants 142 (77.1%) were males and 42 (22.9%) were females. Out of total 184 NAFLD cases 70 (42.9%) were obese patients with BMI of more than 30kg/m2, whereas 54 (33.1%) were pre obese patients with BMI between 25 to 29.9 kg/m2. Positive correlation noticed between waist circumference and Body mass index with p value <0.05 and r value of 0.466 and Waist to Hip ratio showed a negative correlation with body mass Index (P>0.05). It was found that 62 (33.69%) cases were with Type 2 Diabetes Mellitus Waist circumference was found to be useful indicator for obesity with NAFLD patients in comparison with the waist to hip ratio. Significant association noticed between type 2 Diabetes Mellitus and Obesity of NAFLD patients. Strategies need to be planned to train health care workers and teachers about measuring the waist circumference and the body mass index and also interpretation Keywords: Body Mass Index, Waist Circumference, Waist to Hip Ratio, Hypertension

Body Mass IndexWaist CircumferenceWaist to Hip RatioHypertension
33,677 views
10,071 downloads

Contributors:

 DEVARKONDA VENKATESWARLU
,
 B. T. Rao
Research PaperID: BJMHR0603004

Virtual Screening Based Synthesis of Analogs of Quercetin As Insulin Receptor Activators And In-Vivo Comparative Evaluation For Anti-Diabetic Activity

aishwarya sureshrao patil, Sachin A P ishawikar, Harinath N More, S. G. Killedar

ABSTRACT Literature reveals that quercetin shows hypoglycaemic active by more than one way. In present work virtual docking study of quercetinand its probable analogs was carried out on insulin receptor PDB ID:1IR3by using biopredicta module of Vlife MDS 4.3.In results of virtual screening it was found that 2-(3, 4 dihydroxy phenyl)-3,5,7-trihydroxy-4H chromen-4-one(quercetin) and its probable analogs 3-hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one (analog 1), 3,7-dihydroxy-2-(3-methoxyphenyl)-4H-chromen-4-one(analog5)and 3-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4- one(analog7) showed promising results and hence were synthesized. The results of in- vivo screening confirm the results of virtual screening as analogs 1, 5 and 7 have shown better activity hypoglycamic activity than quercetin. Keywords: Quercetine, synthetic analogs, Diabetes mellitus, Virtual screening

Quercetinesynthetic analogsDiabetes mellitusVirtual screening
33,913 views
10,188 downloads

Contributors:

 aishwarya sureshrao patil
,
 Sachin A P ishawikar
,
 Harinath N More
,
 S. G. Killedar
Research PaperID: BJMHR0603005

New Face of Clinical Teaching and Learning: Social Media in Medical Education Use of WhatsApp among Medical Students in Clinical Teaching at Oman Medical College

Firdous Jahan, Muhammad A Siddiqui, Dr Zaid A Mukhlif, Khulood Abdullah Al Kalbani, Aya Issa Al Rawahi

ABSTRACT Medical education has its core values of confidentiality and formal conduct while social media involved sharing and openness, connection which seems to be contradictory for medical professionalism. Main purpose of this study was to explore the students' perception, attitudes and barriers about the professional use of social media and to assess the experiences of undergraduate on the improvement of clinical teaching through the incorporation of social media applications. A cross sectional survey based study was carried out at Oman Medical College. All final year students consented to participate were included in the study. Data was collected on self-administered questionnaire in which core elements were divided – demographics, type and frequencies of different social media usage, student’s perception about WhatsApp utilization and barriers of not using social media. Statistical analysis was performed using SPSS (IBM SPSS Statistics 20.0). Data were expressed in frequencies, mean and percentages. A total of 76 participants were enrolled in which 5 (6.6%) were male and 71 (93.4%) were aged between 20-25 years of age. Among all 57 (75%) were Omani nationals and almost all (98.7%) participants used social media of which 35 (46.1%) were android, 29 (38.2%) IOS, and 12 (15.8%) were other operating system users. All participants daily spend some time on YouTube, Facebook, Twitter and WhatsApp. In contrast, responses of all participants’ indicated that they never make use of Wiki, Chat On and hangout. More than half of the study participants believed that lack of internet access is one the main barrier of non-utilization of social media. Medical students prefer online media for communication and medical information along with usage of WhatsApp in medical education and learning is helpful for improving and enhancing the interactive learning. The students’ response emphasizes positive response and experiences of their learning and discussions provided an effective space for integrated small group clinical teaching and learning. Keywords: Social media, medical education, WhatsApp, clinical teaching, learning

Social mediamedical educationWhatsAppclinical teachinglearning
33,968 views
10,122 downloads

Contributors:

 Firdous Jahan
,
 Muhammad A Siddiqui
,
 Dr Zaid A Mukhlif
,
 Khulood Abdullah Al Kalbani
,
 Aya Issa Al Rawahi
Research PaperID: BJMHR0603006

A REVIEW ON PROBABLE MODE OF ACTION OF HERBAL FORMULATION FOR PILES- PYLEE

Darshani Sonavaria, Chetna Chotalia, Kavita Salkar, Rajiv Salvi

Background: Piles is a medical condition known as haemorrhoids wherein the veins inside or outside the anus or lower rectum gets inflamed or swollen. Symptoms of piles include feeling of soreness, irritation or pain while passing stool accompanied with bleeding. It is generally caused by faulty diet and genetic tendencies. Constipation and piles are interrelated, with one aggravating the condition of other. Hemorrhoids is a common anorectal disorder that hampers the daily activity of suffered person and imposes embarrassment associated with it. Objective: To review possible mode of action of herbal formulation for piles. Methods: Herbal formulation containing unique combination of five plant based ingredients like Azadirachta indica, Terminalia chebula, Symplocos racemosa, Curcuma longa and Glycyrrhiza glabra are beneficial in piles management which helps to control bleeding, prolapse, pain and mucus discharge, and reduces the size of the pile mass in all degrees of piles. Results: A product with multi ingredient, each with a different activity profile would be an ideal product for piles management. This natural herbal formulation is safe and efficacious for piles and anorectal disorders.

PilesHaemorrhoidsAnorectal disordersHerbal Anti Haemorrhoidal formulationPhytoformulationPylee
34,280 views
10,172 downloads

Contributors:

 Darshani Sonavaria
,
 Chetna Chotalia
,
 Kavita Salkar
,
 Rajiv Salvi
Research PaperID: BJMHR0603007

Cytological and Histological Studies on the Hepatotoxic Effects of Sorafenib (Nexavar) in Albino Rats

Eman AbdElla, Abdelkarime mohamed Abdelatif

Background: Sorafenib (Nexavar) is an oral inhibitor of multi-kinase proteins approved in 2005 for treatment of metastatic advanced hepatocellular carcinoma. It causes many metabolic side effects, including diarrhea, hypertension, hand-foot skin reaction, and fatigue. This study aims to detect the histopathological, histochemical and DNA contents changes of the rat's liver under Nexavar treatment. Methods: The rats were divided into 3 groups. • Group 1: Served as control (rats were orally administrated with ml of normal saline for a month. • Group 2: Rats of this group were treated with the multikinase inhibitor Sorafenib (60 mg/kg body weight/day) for 15 days by gavage. • Group 3: Rats of this group were treated with the multikinase inhibitor Sorafenib (60 mg/kg body weight/day) for 30 days by gavage. Animals were sacrificed and specimens from the liver were processed for histopathological, histochemical; by estimation of total carbohydrates and total protein contents; and cytological studies by estimation of DNA contents at the different stages of the cell cycle by the flow cytometer analysis. Results: In treated animals, there were histopathological and histochemical alterations, as a destruction of the normal hepatic architecture, swollen hepatocytes with vacuolar degenerated cytoplasm. Some hepatocytes showed mild to severe signs of injury such as swelling of their nuclei. Karyolysis of other hepatocytes are encountered. Severe reduction in the glycogen and proteins contents of the hepatocytes was observed by using PAS and bromophenol blue staining techniques. Moreover, the results showed that Nexavar causes apoptosis by 15.41% and 13.72% in both groups 2 and 3, respectively. Liver genotoxicity induced by Nexavar for 15 and 30 days decreases the G1 cells constitute to 5.08% and 6.50% and increases the S-phase cells constitute to 19.17% and 20.28%, respectively. Moreover, the G2 cells increases to 2.32% and 2.45, about half of the last amount is aneuploidy cells. Conclusion: Nexavar treatment showed mild to moderate hepatotoxic effects and induces many histological, histochemical and cytological changes causing liver damage.

NexavarHepatotoxicityhistopathologyPASBromophenol blueFlowcytometry.
34,451 views
10,234 downloads

Contributors:

 Eman AbdElla
,
 Abdelkarime mohamed Abdelatif