coronavirus

As per the reports of World Health Organisation (WHO), the first positive case of novel coronavirus infection (COVID-19) triggered on 8th of January 2020 in China and the disease as on 2020 May 13, prevalent over 215 countries. During this period, the virus have claimed over two lac lives and infected over twenty nine lac people around the globe despite substantial prophylactic measures and modernized health-care facilities. The virus causing COVID-19 pandemic outbreak was named as severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) and is believed to be transmitted initially from animals to human and later occurrence of person-to-person transmission is reported. India adopted “Lock Down” throughout the country as a strategic measure, well in advance to combat the disease like most of the other foreign countries. As a consequence, all types of large and small industrial sectors have been badly affected, resulting in a major socio-economic impact. The pandemic has created an unprecedented level of risk, causing investors to suffer significant losses in a very short period of time which is the worst crash since 1987 and there is a knock of $1.1 trillion, off the expected growth of global Gross Domestic Product (GDP). The government of India and most of the other countries has declared special packages for the workers of unorganized sectors, women, small and medium sized industries to deal with the situation. This review will focus on the overall information regarding the virus, global transference pattern analysis, socio-economic impact, treatment and management strategies by different countries and strategies to prevent future viral pandemics like this COVID-19 outbreak.

Viral infection caused by corona virus named 2019-nCov has become pandemic affecting over 200 countries and leading to over 0.25 million deaths worldwide. At present there is no approved drug available specific against 2019-nCov. The present research work is focused on preliminary molecular docking evaluation of forty already available anti-viral drugs using 2GTB and 2GX4 Mpro proteins complexes. The docking simulation study result indicates that Ponatinib with highest docking score might be useful against 2019-nCov whereas, Delavirdine, Idoxuridine, Raltegravir with good docking score may be considered to treat 2019-nCov. The present article may be used by researchers to further detailed evaluation of these drugs as well as by medical professionals to fight against this infection.