autoimmune disease

Some autoimmune conditions have been associated with reduced vitamin D levels, has been associated with vitamin D insufficiency. Reports showed that serum 25-hydroxyvitamin D levels are inversely associated with chronic inflammatory systemic diseases. The main objective of this study was to estimate 25-hydroxyvitamin D level in patients with psoriasis in comparison with control subjects without this disease. Total of 188 (90 male and 98 female) patients with psoriasis were selected and included in the study. Eighty non-psoriatic individuals (40 male and 40 female) with different ages were included as controls.Levels of 25-OH vitamin D were determined using ELISA test kits (Euroimmun-Germany). serum concentrations of vitamin D were significantly lower in psoriatic patients than in control 19.52±10.03 pg/ml, and 40.39±9.06 pg/ml, respectively. The mean of duration of the disease was 13.08±10.5. The mean age of patient was 33.7±14.6 and of control group was 28.0±7.4. There is insignificant difference between concentrations of vitamin D in female compared to male 21.8±10.7 and 17.2±8.9, respectively, P=0.143. Insignificant correlation was found between duration of disease concentration of Vitamin D, P=0.259. The finding of this study showed that the hypovitaminosis Dwas associated with psoriasis disease in Sudan. Gender and duration of the disease were not associated with vitamin D level.