Stroke

Cerebrovascular diseases have recently emerged as a major health problem affecting the elderly population. Volume of the blood is one factor which can determine the prognosis of the patient with intracerebral hemorrhage. A prospective observational study was done at Neurology ward of Chittagong Medical College Hospital (CMCH). The aim of this study was to determine the 30-day mortality of intracerebral hemorrhage in a hospital population and to determine the most important predictor of 30-day outcome. Seventy cases of spontaneous intracerebral hemorrhage were analyzed and followed up for 30 days in hospital and house where necessary. Statistical analyses were performed to see the outcome in relation with blood volume by SPSS-18. In this study, 50(71.42%) patients had hypertension. Diabetes mellitus was found among 6(8.57%). aphasia was found 40(57.1%) patients, dysarthria was in 11(15.7%), motor deficit in 65(92.9%) patients, 48(68.6%) patients had cranial nerve involvement and 32(45.7%) patients had abnormal fundoscopic findings. Regarding analysis of volume of hemorrhage, <5 ml was found in 9(12.9%) patients, 5-15 ml was found in 32(45.7%) patients, >15-30 ml was found in 15(21.4%) patients, >30-60 ml was found in 10(14.3%) patients and >60 ml was in 4(5.7%) of patients. Among all patients, no of death was 9(12.8%) within 30 day and rest 61(87.2%) were alive. After analysis, it was found that fatal outcome is more with increased volume of hemorrhage (p<0.05). It was 100% with >60ml of hemorrhage. Volume of intracerebral hemorrhage is a powerful and easy-to-use predictor of 30-day mortality in patients with spontaneous intracerebral hemorrhage.

Abstract Falije Nisfi (Hemiplegia) is a disease causing loss of sensations and movements in longitudinal half of the body. It is the commonest form of paralysis, occurring due to cerebrovascular accident or stroke. Despite the advancements in modern technology and drug development, the figures in terms of deaths and disability caused by stroke grossly suggest the limitations in its management. Unani system of medicine asserts to possess treatment for recovery in Falije Nisfi (Hemiplegia). Unani Physicians such as Buqrat, Jalinoos, Ibne Sina, Razi and all successors have discussed Falije Nisfi (Hemiplegia) and described the risk factors, etiology, signs and symptoms, pathophysiology, prognosis, treatment and complications in detail. In this article authors delineate the Unani concept of Falije Nisfi (Hemiplegia).

Stroke is a serious condition in which specific area of the brain will loss the blood supply. When blood restored to the ischemic area the risk will be increased and brain cells will undergo cell death by the two known forms of cell death (apoptosis and necrosis). Methionine is an essential amino acid needed by our body for many physiological pathways like synthesis of glutathione which is considered as more important endogenous antioxidant molecules. This study was designed to assess the possible neuroprotective activity of L-Methionine in cerebral I/R injury after bilateral common carotid artery occlusion (BCCAO) in rats. A total of 24 Adult Sprague-Dawley rats were used. They divided equally into four groups (sham, control, control vehicle and L-methionine treated groups). Their brains were removed and prepared by a reported procedure for histopathological study and staining with 2, 3, 5-triphenyltetrazolium chloride (TTC). It has been found that both histopathological and TTC staining results showed a significant role for L-Methionine as cerebroprotective agent and further studies are recommended to confirm that.