High sensitive C-reactive protein (Hs-CRP)

Background and Aims: Type 2 diabetes is not one disease but rather a heterogenous group of syndromes characterized by elevation of fasting blood glucose. Highly sensitive C-reactive protein (Hs-CRP) is an acute phase reactant and a sensitive marker of inflammation. Hyperglycemia can potentially promote the production of Hs-CRP. The aim of this study was to correlate the association of fasting blood glucose with Hs-CRP and some other cardio metabolic concentrations. Methods: A total number of 355 adults, age 30-60 yrs, subjects were recruited in the study. Of them 192 subjects was non diabetic (control) group and 163 was diabetic (study) group. Vital statistics were taken along with measurement of blood glucose, triglyceride, total cholesterol, high density lipoprotein, low density lipoprotein and Hs-CRP levels. Data were analyzed using statistical Package for Social Program (SPSS) for Windows version 17. Results: In comparison to non diabetic subjects, diabetic are significantly older (P=0.001), have higher BMI (P=0.001), higher waist hip ratio (P=0.042) and higher body fat mass% (P<0.0001). Systolic blood pressure is high in diabetic subjects but not statistically up to significant level but diastolic blood pressure is high (P=0.016). In biochemical parameters Triglyceride (P=0.001) and Hs-CRP (P<0.001) are significantly higher and High Density lipoproteins (HDLs) are significantly lower (P=0.030) in diabetic subjects. Conclusion: Anthropometric parameters are found to be high in diabetic subjects compared to non diabetic subjects. High level of Hs-CRP, Triglyceride and low level of HDL-c is also observed in diabetic subjects. Literature is reviewed accordingly.