Dental implants

ABSTRACT The aim of this systematic review to evaluate the effect of diabetes on dental implants loss. Review authors searched 3 electronic databases; Pubmed, Cochrane and Lilacs: 11/10/2018, hand searched 11 journals till November 2018 and snowballing: 15/10/2018. Adult female and male patients above 18 years old, either completely or partially edentulous, maxillary and/or mandibular dental implants, restored by fixed or removable prosthesis, were included. Surgical modifications, drugs that affect bone density, like vitamin D and biphosphonates, were excluded. Diabetic patients, who are classified either controlled or uncontrolled were considered eligible. Review authors extracted data relevant to PECOT. Data was descriptively and statistically analyzed. 14 studies; 9 prospective and 5 retrospective studies, involving 1398 participants and 3282 implants, were included in this systematic review. 3 studies were included in the meta-analysis. Based on the results of implant loss 2 years following implant placement, implant therapy in diabetic patients seems to be possible. However, results should be taken with extreme cautions, since the quality of evidence is very low. Keywords: Diabetes mellitus, high blood sugar, Dental implants, Oral implants

Objective: the objective of this study was to histologically and immunologically analyze the level of bone substitution and the presence of new blood vessels in a nanobiomaterial composed of hydroxyapatite and BTCP in a maxillary sinus lift surgery. Methods: A case of a maxillary sinus lift was investigated. The patient had a 1.0 mm bone remnant on the left side and 2 grams of nanobiomaterial (80% hydroxyapatite and 20% β-tricalcium phosphate) were grafted into the pneumatized sinus. After 6 months, during dental implant placement surgery, grafted bone samples were collected with 4 mm trephines. These samples were sent to the laboratory for analysis where they were stained with masson's trichrome and immunostained with osteonectin and osteopontin. Results: after 6 months of bone regeneration a result of 14 mm of bone gain was reached, the analyzes in masson's trichrome showed an excellent gain of newly formed bone, in addition to a very high percentage of blood vessels. In the immunostaining, a very large number of osteoblasts and osteoclasts was observed, signaling an excellent osteoconductive and osteoinductive potential of the studied nanobiomaterial. Conclusions: the maxillary sinus lift surgery with nanobiomaterial provided a very favorable bone height and thickness gain, as well as the high vascularity and cellularity, which enabled the patient's oral rehabilitation with osseointegrated dental implants and permanent ceramic prostheses.