Velpandian V

ABSTRACT Liver is a vital organ for metabolism and it is affected due to various diseases and toxic products. It also plays an important role as bio Transformer of xenobiotic which are more toxic and more reactive substances. Though there are some liver tonics in modern medicine, Siddha medicine has innumerable formulations to protect the liver. Jaundice is an important sign of liver disorder. Hepatocellular carcinoma is the commonest cause of liver cancers which leads to 5th common cause of cancers affecting mankind. Liver cirrhosis is the common cause of liver disease in India. There is a need of safe hepatoprotective drug from Siddha system of medicine. The available information was collected from various Siddha and modern literature, scientific databases such as PubMed, Science Direct, Scopus, Web of Science and Google Scholar etc. One such hepatoprotective drug is Saman Chooranam. But there is no sufficient collective literature report and scientific validation of this formulation. The significance of this review is aimed to provide a brief and collective scientific evaluation of the key active phytochemical components and its pharmacological actions for the possible development of this formulation Saman Chooranam in future perspective. This review reveals that the traditional use, phytochemistry and pharmacological profile of Siddha herbomineral formulation of Saman Chooranam thereby identifying the research lacuna and future steps regarding this drug. Keywords: Siddha medicine, Saman Chooranam, Hepato protective, Herbomineral.

ABSTRACT Thiriloga Chindhamani Pills (TCP) is commonly used in Siddha system of medicine for its analgesic, anti-inflammatory and anti-arthritic properties. However, these activities have not been scientifically validated through experimental procedures and clinical trials. So the present work was carried out to evaluate the above activities of TCP in rats. Hot Plate model was used to determine the analgesic activity. Two doses of TCP (100 mg and 200 mg/kg) was used and Diclofenac Sodium was used as standard. Among the two doses 200mg/kg showed highly significant analgesic activity indicated the analgesic activity of TCP in dose dependent manner. Evaluation of anti-inflammatory activity was carried out by carrageenan induced acute inflammatory model in rats. TCP100, TCP200 and reference drug Indomethacin was administered. The results showed that there was a significant difference in oedema size between all the tested groups. TCP 200 exhibited highly significant effect which is similar to that of standard drug. Evaluation of the antiarthritic activity of TCP was evaluated on Freund's complete adjuvant induced arthritic model. Two doses of TCP (100 and 200 mg / kg) and the reference drug Prednisolone 10mg/kg were administered. Both the positive control and two doses of Thiriloga Chindhamani Pills decreased the inflammatory process and TCP 200 significantly decrease the inflammation when compared to the control. This work has shown that Thiriloga Chindhamani Pills have analgesic, anti-inflammatory and anti-arthritic activities, which would justify their traditional use in Siddha system of medicine.