NALINA SARASAWATHI Kolappan

ABSTRACT Thiriloga Chindhamani Pills (TCP) is commonly used in Siddha system of medicine for its analgesic, anti-inflammatory and anti-arthritic properties. However, these activities have not been scientifically validated through experimental procedures and clinical trials. So the present work was carried out to evaluate the above activities of TCP in rats. Hot Plate model was used to determine the analgesic activity. Two doses of TCP (100 mg and 200 mg/kg) was used and Diclofenac Sodium was used as standard. Among the two doses 200mg/kg showed highly significant analgesic activity indicated the analgesic activity of TCP in dose dependent manner. Evaluation of anti-inflammatory activity was carried out by carrageenan induced acute inflammatory model in rats. TCP100, TCP200 and reference drug Indomethacin was administered. The results showed that there was a significant difference in oedema size between all the tested groups. TCP 200 exhibited highly significant effect which is similar to that of standard drug. Evaluation of the antiarthritic activity of TCP was evaluated on Freund's complete adjuvant induced arthritic model. Two doses of TCP (100 and 200 mg / kg) and the reference drug Prednisolone 10mg/kg were administered. Both the positive control and two doses of Thiriloga Chindhamani Pills decreased the inflammatory process and TCP 200 significantly decrease the inflammation when compared to the control. This work has shown that Thiriloga Chindhamani Pills have analgesic, anti-inflammatory and anti-arthritic activities, which would justify their traditional use in Siddha system of medicine.