Hypercholesterolemia Due to Chronic Renal Failure in Diabetic ‎Sudanese Patients

This study was conducted to compare the quantitative and qualitative aspects of serum ‎cholesterol in chronic renal failure (CRF) patients due to diabetes with that of CRF in patients ‎due to other causes, and assessing the possibility for developing atherosclerotic cardiovascular ‎disease. The study was conducted in 80 Sudanese patients on haemodialysis and peritoneal ‎dialysis, 40 of them had CRF due to Diabetes mellitus and others had CRF due to other ‎causes. Additional 40 health Sudanese served as control. Serum samples were analyzed using ‎standard colorimetric methods to detect concentration of the total cholesterol, triglycerides, ‎high density lipoprotein. In CRF patients due to diabetes mellitus there was significant ‎increase in serum cholesterol level, also there was consequent decrease in high density ‎lipoprotein. The mean of total cholesterol was 255 mg/dl in the first group and in the second ‎was 183 mg/dl, triacylglycerols was 177 mg/dl for the first group and for the second group ‎was 163 mg/dl, low density lipoproteins was 187 mg/dl for the first group and for the second ‎group was 113 mg/dl, high density lipoprotein cholesterol was 27 mg/dl for the first group ‎and 31 mg/dl for the second group. There was no effect of sex, age and the duration of renal ‎failure. This study demonstrated the effect of diabetes mellitus on lipoprotein level in patients ‎with CRF as one of the atherosclerotic risk factor.‎