Hypolipidaemic Activity of Seeds of Spermacoce hispidaLinn., in Isoproterenol Induced Cardiotoxic Rats

Lipids play a vital role in pathogenesis of cardiovascular disease by causing hyperlipidemia which in turn, leads to the development of atherosclerosis. Hyperlipidaemia is found to be one of the greatest risk factor for the development of coronary heart disease. The available hypolipidaemic drugs have been associated with number of side effects and people are interested in natural therapies. Our previous studies proved that Spermacocehispida exhibit cardio-protective effects by several mechanisms. Spermacocehispida possesses significant anti-oxidant and cardioprotective activities. The present study aimed to investigate the hypolipidaemic effects of Spermacocehispida seed extract on isoproterenol (ISO) induced cardiotoxic rats. Two different doses of the Hydro alcoholic extract of plant such as 100 and 200 mg/kg body weight was used to prove the hypolipidaemic activity against 100mg/kg body weight of (ISO).After administration of S. hispida shows a significant decrease in the levels of cholesterol, triglycerides, LDL, VLDL and significant increase in the level of HDL in serum and heart tissues. Therefore it effectively suppressed the ISO induced hyperlipidemia in rats, suggesting the potential protective role in Coronary heart disease.