S. M. Kharade

ABSTRACT The present work is an attempt to assess the in- vitro anthelmintic activity of the leaves and seed extracts of Caesalpinia decapetala (Roth). The crude drug was extracted in alcohol and water by using maceration extraction procedure. These extracts are used for assessment of in-vitro anthelmintic activity by using traditional earthworm technique. Doses of various concentration of extracts are prepared and earthworms are allowed to expose to them. Time of paralysis and death was observed and recorded as observations. In-vitro antihelmintic study of C. decepetala showed promising results. The perusal of the data reveals that the hydroalcoholic extract of the leaves at concentration of 10mg/ml, 20mg/ml, 40mg/ml, 50mg/ml and 100mg/ml showed paralysis and death time in 108, 63, 32, 15, 5& 138, 83, 48, 21, 11 mins. and the seed extract at same concentrations shows both paralysis and death at 63, 48, 25, 21, 4 and 87, 62, 32, 26, 9 mins respectively. Conclusion: The anthelmintic activity of leaves and seed plant extract of Caesalpinia decapetala (Roth) Alston. Was carried out on earth warm. Different concentrations of the hydroalcoholic extracts were used for the studies. The time taken for paralysis and death of earthworms were recorded. The extract showed paralysis followed by death of the worms at all tested dose levels.