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📢 Latest Update: Call for Papers: Special Issue on Medical and Health Research – Submit to British Journal (BJMHR) by March 31, 2026

📢 Latest Update: Call for Papers: Special Issue on Medical and Health Research – Submit to British Journal (BJMHR) by March 31, 2026

Volume 6, Issue 6 - 2019 (June 2019 Issue 6)

Volume 6 Issue 6 Cover

Issue Details:

Volume 6 Issue 6
Published:Invalid Date

Editorial: June 2019 Issue 6

Welcome to the 2019 issue of British Journal of Medical and Health Research. This issue showcases the remarkable breadth and depth of contemporary research across multiple disciplines. From cutting-edge applications of machine learning in climate science to the revolutionary potential of quantum computing in drug discovery, our featured articles demonstrate the power of interdisciplinary collaboration in addressing global challenges.

We are particularly excited to present research that bridges traditional academic boundaries, reflecting our journal's commitment to fostering innovation through cross-disciplinary dialogue. The integration of artificial intelligence with environmental science, the application of blockchain technology to supply chain management, and the convergence of urban planning with smart city technologies exemplify the transformative potential of collaborative research.

As we continue to navigate an era of rapid technological advancement and global challenges, the research presented in this issue offers both insights and solutions that will shape our future. We thank our authors, reviewers, and editorial board members for their continued dedication to advancing knowledge and promoting scientific excellence.

Dr Hemangi J Patel
Editor-in-Chief
British Journal of Medical and Health Research

Articles in This Issue

Showing 5 of 5 articles
Research PaperID: BJMHR0606001

“FORMULATION & EVALUATION OF ANTI-HEAD LICE ACTIVITY OF HERBAL GEL”

VIKAS PATIL, PRAKASH HIRAMAN PATIL

Gels are transparent to opaque semisolid containing gelling agent that merges or entangles to form a three dimensional colloidal network structure. Its responsible for a gel resistance to deformation and its visco-elastic properties. Gels have better potential as a vehicle to administer rug topically in comparison to ointments because they are non-sticky, require low energy during formulation, have aesthetics value and are stable. The physical appearance was simply checked by colour, odour, taste. In this a homogeneity and texture of prepared gel was also determined. Viscosity was determine using Brookfeild digital viscometer. 5gm prepared gel sample was placed in sample holder of B. Viscometer using spindle no.6 at 25 0c and allowed it to settle for 5 min and viscosity measured by rotating it at different rpm. Antiheadlice activity was determined by using antibacterial method by diffusion assay or cylinder plat or cup- plate method.

Diffusion assayantiheadlice activityantibacterial activity.
35,391 views
10,652 downloads
DOI:
10.46624/bjmhr.2019.v6.i06.001

Contributors:

 VIKAS PATIL
,
 PRAKASH HIRAMAN PATIL
Research PaperID: BJMHR0606002

GLYCEROL TO PREVENT CORNEAL HAZE POST PHOTOREFRACTIVE KERATECTOMY SURGERY IN HIGH DIOPTERS: BIOCHEMICAL AND PHYSIOLOGICAL BASIS.

Isabel De la Fuente, Leopoldo Garduño Vieyra, Luis Antonio Rivera Abril, Luis Manuel Zamora y Cornejo, Francisco J Rodríguez Ramírez, Maria Teresa Zavala Martínez

The purpose of this study is to find an effective treatment without corneal haze in patients with high diopters and/or thin corneas; the idea is to offer them a safe surgical refractive treatment to improve their visual acuity (VA) without the use of intraocular implants for higher diopters avoiding therefore any associated risk. A retrospective, observational and descriptive case series included 75 eyes with ametropias with spherical equivalents the lowest -5.00 Diopters, the highest -22.00 Diopters who underwent photorefractive keratectomy. They were treated additionally with mitomycin 0.02%, contact lens, tobramycin/dexamethasone, and sodium hyaluronate for seven days. Upon removal of the contact lens, they were treated with glycerol 0.9% and sodium hyaluronate three times a day for two months. The 75 eyes included had a preoperative visual capacity was of 1.57 logMAR (SD 0.5), and postoperative of 0.1 logMAR (SD .12) (T test for paired samples, p=000) (FIGURE 2). Preoperative pachymetry was of 564.7 (SD 43.3) and postoperative of 449.1 micra (SD 55.9), (T test for paired samples, p=0.000). There were 5 cases of haze at the first postoperative month, no case of haze was presented at 3, 6 and 12 months of follow-up. This study shows that the use of glycerol is an effective treatment as an adjuvant to prevent haze; based on its osmolarity, hygroscopic capacity and its protein stabilizing properties.

GlycerolHygroscopicHazeKeratocytesAmetropia
35,261 views
10,617 downloads
DOI:
10.46624/bjmhr.2019.v6.i06.002

Contributors:

 Isabel De la Fuente
,
 Leopoldo Garduño Vieyra
,
 Luis Antonio Rivera Abril
,
 Luis Manuel Zamora y Cornejo
,
 Francisco J Rodríguez Ramírez
,
 Maria Teresa Zavala Martínez
Research PaperID: BJMHR0606004

Investigation of Anthelmintic Activity of Caeselpinia decapetala (Roth) Seed and Leaves Extracts

A. A. Veer, S. M. Kharade

ABSTRACT The present work is an attempt to assess the in- vitro anthelmintic activity of the leaves and seed extracts of Caesalpinia decapetala (Roth). The crude drug was extracted in alcohol and water by using maceration extraction procedure. These extracts are used for assessment of in-vitro anthelmintic activity by using traditional earthworm technique. Doses of various concentration of extracts are prepared and earthworms are allowed to expose to them. Time of paralysis and death was observed and recorded as observations. In-vitro antihelmintic study of C. decepetala showed promising results. The perusal of the data reveals that the hydroalcoholic extract of the leaves at concentration of 10mg/ml, 20mg/ml, 40mg/ml, 50mg/ml and 100mg/ml showed paralysis and death time in 108, 63, 32, 15, 5& 138, 83, 48, 21, 11 mins. and the seed extract at same concentrations shows both paralysis and death at 63, 48, 25, 21, 4 and 87, 62, 32, 26, 9 mins respectively. Conclusion: The anthelmintic activity of leaves and seed plant extract of Caesalpinia decapetala (Roth) Alston. Was carried out on earth warm. Different concentrations of the hydroalcoholic extracts were used for the studies. The time taken for paralysis and death of earthworms were recorded. The extract showed paralysis followed by death of the worms at all tested dose levels.

STHMorbidityAyurvedaAnthelminticEarthworm method.
35,738 views
10,679 downloads
DOI:
10.46624/bjmhr.2019.v6.i06.003

Contributors:

 A. A. Veer
,
 S. M. Kharade
Research PaperID: BJMHR0606005

To Study The Effect Of Magnesium Sulfate On Rhythm Disturbances While Coming Of Cardio Pulmonary Bypass In Patients Undergoing cardiac Surgery

SATISH KUMAR MISHRA, M N Veena, Sumit . Mishra

Objective: To evaluate the effect of intravenous magnesium sulfate on post-operative complications when given prophylactically while coming of cardio pulmonary bypass (CPB) in patients undergoing cardiac surgery. Methodology: A double-blinded randomized studyconducted at a tertiary care center in western Maharashtra from Nov 2017 to April 2019. Patients were divided into two groups. Group A (Magnesium sulfate group) (n=130) & Group B (control group) (n=130). Patients undergoing on pump Coronary artery bypass grafting (CABG), Mitral valve replacement/repair (MVR), Aortic Valve Replacement (AVR) or both AVR & MVR (DVR) on CPB were included in the study.Once surgery was over, aortic cross clamp taken out & temperature of 36°c was attained, Group A patients received Injection Magnesium sulfate 1 gm IV slowly over 10 minutes.Patients were monitored for heart rate, intra-arterial blood pressure oxygen saturation, continuous electrocardiograph with automatic ST segment analysis apart from this ECG mapping was done. Results:There was no significant Statistical difference regarding the demographic data, comorbidities & ejection fraction between the two groups. The result shows a statistically significant difference (P=0.032) between the two groups with regards to the incidence of atrial fibrillation. In group A 10 patients (7.70%) had atrial fibrillation compared to group B where 28 patients (21.6%) had atrial fibrillation.Weaning from CPB was easier in group A patient compared to group B & also group A patient needed smaller doses of pharmalogical support, than group B. Conclusion: A single bolus 1Gm dose of magnesium sulfate while coming off from CPB has an excellent effect in reducing the incidence of atrial fibrillation. Further magnesium reduced the amount of pharmacological support which was required to come off CPB.

CABG: Coronary artery bypass graftingMVR: Mitral valve replacement/ repairAVR: Aortic valve replacementDVR: Dual valve replacementIABP: Intra-aortic balloon pumpCPB:Cardio-Pulmonary Bypass.
35,519 views
10,745 downloads
DOI:
10.46624/bjmhr.2019.v6.i06.004

Contributors:

 SATISH KUMAR MISHRA
,
 M N Veena
,
 Sumit . Mishra
Research PaperID: BJMHR0606006

Production of the Anti-Leukemic Therapeutic Enzyme, L-Asparaginase, by A Brackish Sediment Strain of Aspergillus candidus

Atim . Asitok, Maurice . Ekpenyong

Aspergillus candidus strain IR-A4 was isolated from the brackish sediment of Itu River, Akwa Ibom State, Nigeria on Czapex-Dox yeast-extract agar and screened for L-asparaginase production by the rapid plate technique and in submerged fermentation. Protein was detected in cell-free fermentation broth by the Bradford method and confirmed as L-asparaginase by rapid development of pink colour on asparagine-minimal medium. The protein was partially purified by (NH4)2SO4 precipitation and dialysis against Tris-HCl buffer. L-asparaginase activity, evaluated by the colorimetric Nesslerization method, was 1282 ± 70.5 U with a specific activity of 17.26 U/mg. The enzyme demonstrated very minimal glutaminase specific activity of 0.03 U/mg with a 352-fold lower specific activity relative to L-asparaginase activity suggesting near-free allergic reactions in the course of therapy. The anti-leukemic activity of the enzyme, demonstrated by in vitro cytotoxicity assay using HL-60 cell lines, showed that 87.98% of the dialyzed fraction of the enzyme could destroy 50% (IC50) of leukemic cells. There was 97% association, ω2, between fermentor size and enzyme activity suggesting great potential for large-scale fermentative production of the therapeutic enzyme. Optimal conditions for enzyme activity were set at (i) Substrate concentration, 220-260 mM (ii) pH 8-9 and (iii) Temperature, 35-45ºC. The mould is recommended for large-scale production of low-glutaminase activity L-asparaginase for treatment of lymphoblastic leukemia patients.

Aspergillus candidus strain IR-A4L-asparaginase productionGlutaminase activityAnti-leukemic activity.
36,020 views
10,762 downloads
DOI:
10.46624/bjmhr.2019.v6.i06.005

Contributors:

 Atim . Asitok
,
 Maurice . Ekpenyong

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