Ameliorative Effects of Some Plant Seeds against side effects of antiobesity drug on Rats

this study aimed to investigate the antiobesity effects of l`upin (L) and/or purslane (P) on obese female rats, Methods: 90 female albino rats divided into 9 groups. GPI (control non obese) fed on normal diet through 18 weeks and obesity groups were induced by feeding on a high-fat-diet during 3 months. At 310 ± 10 g, eighteen obese female rats were divided into eight groups and fed a high fat diet (HFD) or HFD containing either 30% lupin seed powder and / or 30% purslane seed powder or both for 6 weeks as following: GPII (Control obese), GPIV (L), GPV (P), GPVI (L+P), GPVII (St+L), GPVIII (St+P), GPIX (St+L+P). Biochemical parameters as AST, ALT, LDH, and blood urea nitrogen (BUN) and serum creatinine beside histopathological investigation for some vital organs were done. Results: HFD induced obesity in GPII and elevated ALT, AST, LDH, BUN and creatinine. Also starvex drug showed clear anti-obesity effect on obese female rats more than lupin or purslane seeds powders but starvex significantly elevated ALT, AST, LDH, BUN creatinine coincides with the recorded histopathological lesions in the studied paraffin sections. Treatments with lupin and/or purslane seeds powders improve the biochemical elevation and histopathological observations in both control obese and starvex rats indicating their effect against toxicity. Conclusion: starvex toxicity in obese female rats could be reduced by adding lupin seed and/or purslane. .