Toxicological study of Manihot esculenta Crantz (Euphorbiaceae) leaf extracts

MindÃ©dÃ© ( MindÃ©dÃ© ) ASSIH (en); Diallo Aboudoulatif; Dougnon Victorien; Metowogo Kossi; Povi Lawson-Evi; Eklu-Gadegbeku Kwashi; Potchoo Yao; Krunal Yogesh Shah; Aditya K Agrawal; Yash Mahesh Mutha; Prasanna Nitinbhai Shah; Shubham Suryakant Kapadiya; Paresh P Golwala; Ologhaguo Macstephen Adienbo; Victor Opuada Hart

Volume 8, Issue 4 - 2021 (April 2021 Issue 4)

Issue Details:

Volume 8 Issue 4

Published:Apr 3, 2026

Dr J S Patel
Editor in Chief
British Journal of Medical and Health Research

Articles in This Issue

Showing 3 of 3 articles

Research PaperID: BJMHR0804001Pages 1-11

Open Access

Toxicological study of Manihot esculenta Crantz (Euphorbiaceae) leaf extracts

MindÃ©dÃ© ( MindÃ©dÃ© ) ASSIH (en), Diallo Aboudoulatif, Dougnon Victorien, Metowogo Kossi, Povi Lawson-Evi, Eklu-Gadegbeku Kwashi, Potchoo Yao

Manihot esculenta, also named cassava, is a plant widely used as food but also in traditional medicine to treat many diseases such as anemia. However, consumption of M. esculenta is limited by its content in cyanogenic glycosides. Few studies have evaluated the toxicity of M. esculenta leaves. This study aims to evaluate the in vitro cytotoxicity of Artemia salina and the 28 days subchronic toxicity of M. esculenta leaves by oral administration of the extract to male Wistar rats. The A. salina assay showed that the alcoholic extract of M. esculenta presented some toxicity. The results of 28 days subchronic toxicity showed a significant increase in the relative weight of the liver. No changes in hematological parameters were observed apart from a significant increase in platelet number. Biochemical parameters such as SGOT, SGPT, glycemia, and ALP were not significantly changed. The histological sections showed no organ damage.

Manihot esculentacytotoxicityArtemia salinasub-chronic toxicityWistar rats

47,850 views

14,394 downloads

DOI:: 10.46624/bjmhr.2021.v8.i4.001

Contributors:

MindÃ©dÃ© ( MindÃ©dÃ© ) ASSIH (en)

Diallo Aboudoulatif

Dougnon Victorien

Metowogo Kossi

Povi Lawson-Evi

Eklu-Gadegbeku Kwashi

Potchoo Yao

Research PaperID: BJMHR0804002Pages 1-10

Open Access

Wrist arthrodesis : A salvage procedure for 15 months old post traumatic arthritis of wrist joint

Krunal Yogesh Shah, Aditya K Agrawal, Yash Mahesh Mutha, Prasanna Nitinbhai Shah, Shubham Suryakant Kapadiya, Paresh P Golwala

Wrist arthrodesis or wrist fusion is a procedure in which the wrist joint is immobilized by fusion of the radius to the carpal bones. It is considered as a treatment modality for pain relief purposes in conditions such as advanced wrist arthritis following complex communited wrist fractures, cerebral palsy, brachial plexus injuries, and as a salvage technique after failed implant arthroplasty. Wrist arthrodesis is considered as a last resort when all other treatment options have failed to provide relief to patient's symptoms [1]. Total wrist arthrodesis using a rigid plate with use of bone graft from a local source demonstrates an excellent fusion rate.

Wrist arthrodesisWrist jointTFCCLister tubercleDRUJ instabilityLCDCP plate+1 more

48,027 views

14,545 downloads

DOI:: 10.46624/bjmhr.2021.v8.i4.002

Contributors:

Krunal Yogesh Shah

Aditya K Agrawal

Yash Mahesh Mutha

Prasanna Nitinbhai Shah

Shubham Suryakant Kapadiya

Paresh P Golwala

Research PaperID: BJMHR0804003Pages 1-8

Open Access

AMELIORATIVE EFFECTS OF METHANOL EXTRACT OF ENGLERINA DRUMMONDII (MISTLETOE) LEAVES ON DIABETES MELLITUS-INDUCED HYPERGLYCAEMIA AND TESTICULAR DYSFUNCTION IN MALE WISTAR RATS

Ologhaguo Macstephen Adienbo, Victor Opuada Hart

Diabetes mellitus affects more than 100 million worldwide, with a soaring prevalence. Prolonged diabetes results in reproductive dysfunction. Mistletoe is widely used in ethnomedicine, including treatment of infertility. This study is aimed at evaluating effect of Englerina drummondi (mistletoe) leaves on testicular function in diabetic male rats. Methanol Extract of Englerina drummondii Leaves (MEDL) was obtained by soxhlet extraction. Thirty male Wistar rats (170â€“200 g) were grouped into 6 (A â€“ F; n=5). Diabetes Mellitus (DM) was induced in groups D, E and F by administration of 250mg/kg fructose and High Fat Diet (HFD) for 6 weeks. Thereafter, rats in all groups were treated orally for 56 days with either MEDL or Distilled Water (DW) as follows: Group A (control) 1ml DW; B (500mg/kg MEDL), C (250mg/kg MEDL), D (DM + 250mg/kg MEDL), E (DM + 500mg/kg MEDL), F (DM + 1 ml DW; served as diabetic control). Fasting Blood Glucose (FBG) measured on weeks 0, 2, 4, 6 and 8. After treatment, rats were sacrificed, blood collected and serum used for testosterone; epididymal semen for sperm analysis. Results show that MEDL significantly (P<0.05) reduced FBG in groups D and E (3.98Â±0.21 and 4.04Â±0.29mmol/L respectively), compared to group A (3.94Â±0.14mmol/L). Treatment with MEDL to diabetic rats significantly (P<0.05) increased sperm count, viability, and testosterone, while reducing sperm abnormality, compared to diabetic control. It was concluded that Englerina drummondii leaves possess antihyperglycemic effects, and ameliorates testicular dysfunction in diabetic rats.

Englerina drummondiimistletoeDiabetes mellitusSperm qualitytesticular dysfunction

48,102 views

14,433 downloads