Current Issue
Volume 13, Issue 8 - 2026 (August 2026 Issue 8 )
Issue Details:
Volume 13 Issue 8 (August 2026 Issue 8)Issue Description:
Welcome to the 2026 issue of British Journal of Medical and Health Research. This issue showcases the remarkable breadth and depth of contemporary research across multiple disciplines. From cutting-edge applications of machine learning in climate science to the revolutionary potential of quantum computing in drug discovery, our featured articles demonstrate the power of interdisciplinary collaboration in addressing global challenges.
We are particularly excited to present research that bridges traditional academic boundaries, reflecting our journal's commitment to fostering innovation through cross-disciplinary dialogue. The integration of artificial intelligence with environmental science, the application of blockchain technology to supply chain management, and the convergence of urban planning with smart city technologies exemplify the transformative potential of collaborative research.
As we continue to navigate an era of rapid technological advancement and global challenges, the research presented in this issue offers both insights and solutions that will shape our future. We thank our authors, reviewers, and editorial board members for their continued dedication to advancing knowledge and promoting scientific excellence.
Dr J S Patel
Editor-in-Chief
British Journal of Medical and Health Research
Articles in This Issue
ACE inhibitors versus ARBs in Patients with Type 2 Diabetes Mellitus and Hypertension: A Comparative Study of Safety, Blood Pressure Control, and Renal Outcomes.
Both Angiotensin-Converting Enzyme Inhibitors (ACEIs) and Angiotensin Receptor Blockers (ARBs) are recommended first-line agents for hypertension in patients with Type 2 Diabetes Mellitus (T2DM). However, treatment adherence is frequently compromised by class-specific adverse drug reactions (ADRs). This study compares the safety profiles, tolerability, blood pressure control, and short-term renal outcomes of ACEIs versus ARBs in a clinical setting. Methods: A prospective, observational study was conducted over 12 months in a tertiary care teaching hospital. One hundred adult patients ($N=100$) with T2DM and essential hypertension initiating monotherapy with either an ACEI ($n=50$, e.g., enalapril) or an ARB ($n=50$, e.g., losartan) were enrolled. Baseline demographic, clinical, and laboratory safety markers (serum potassium, serum creatinine, and eGFR) were recorded. Safety endpoints included the incidence of dry cough, hyperkalemia, acute kidney injury (eGFR decline greater than 30%), and therapy discontinuation rates. Efficacy was assessed via blood pressure (BP) and urinary albumin excretion rates. Results: Both groups achieved comparable, statistically significant reductions in systolic and diastolic BP, as well as urinary albumin excretion at 12 months ($p > 0.05$ for inter-group comparisons). However, the ARB group demonstrated a significantly superior safety and tolerability profile. Dry cough was reported in 16% of the ACEI group compared to 0% in the ARB group ($p < 0.01$), leading to a therapy discontinuation rate of 10% in the ACEI cohort. Mild hyperkalemia (serum $K^+ > 5.0 \text{ mEq/L}$) occurred in both groups (ACEI: 8% vs. ARB: 6%; $p > 0.05$) without any severe hyperkalemic events or acute kidney injury. Conclusion: While ACEIs and ARBs provide equivalent blood pressure control and renal protection, ARBs offer a significantly superior safety profile with a lower incidence of dry cough and lower treatment discontinuation rates. ARBs may be preferred as a first-line option to optimize long-term treatment adherence in patients with T2DM and hypertension.
Contributors:
SAFETY AND EFFICACY COMPARISION OF CLOMIPHENE CIRATE Vs METFORMIN AND CLOMIPHENE CIRATE COMBINATION IN MANAGEMENT OF PCOS
Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder affecting women of reproductive age, frequently complicated by anovulatory infertility and insulin resistance. Clomiphene citrate (CC) is the established first-line agent for ovulation induction, but a subset of women exhibits clomiphene resistance. Metformin, an insulin-sensitizing agent, has been proposed as an adjunct to improve ovulatory response in these patients. To compare the safety and efficacy of metformin combined with clomiphene citrate versus clomiphene citrate alone in the management of PCOS. This prospective comparative study was conducted in the Department of Obstetrics and Gynaecology, Coimbatore Medical College Hospital, from July 2025 to December 2025. Forty-two women diagnosed with PCOS were allocated to two groups (n=21 each): Group A received CC alone, and Group B received metformin plus CC. Outcomes assessed included ovulation rate, menstrual cycle regularity, conception rate, adverse effects, and metabolic parameters. Baseline demographic, hormonal, and metabolic parameters were comparable between groups (p>0.05). Ovulation, menstrual regularity, and conception rates were significantly higher in the metformin + CC group compared to CC alone (p<0.05 for all outcomes). Gastrointestinal adverse effects — loss of appetite (60%) and nausea/vomiting (18%) — occurred exclusively in the metformin + CC group but did not lead to treatment discontinuation. No cases of ovarian hyperstimulation syndrome, multiple pregnancy, or teratogenicity were observed in either group. Combination therapy with metformin and clomiphene citrate was more effective than clomiphene citrate alone in inducing ovulation, restoring menstrual regularity, and achieving conception in women with PCOS, with a manageable and non-limiting adverse effect profile. Metformin + CC may be considered a preferable first-line option, particularly in women with insulin resistance. Polycystic ovary syndrome, metformin, clomiphene citrate, ovulation induction, insulin resistance.
Contributors:
BIOMECHANICAL CONSIDERATIONS IN CLEAR ALIGNER THERAPY: FORCE DELIVERY, MOVEMENT CONTROL AND THEIR CLINICAL IMPLICATIONS.
Clear aligner therapy (CAT) has evolved as a viable orthodontic treatment approach as digital technology, biomaterials, and biomechanical principles have advanced over time.It was originally used for mild malocclusions, but improvements in aligner design, attachments and digital treatment planning have led to its use in more complex orthodontic situations. This review will present biomechanical principles that define force delivery and tooth movement control and their clinical implications in challenging patients treated with the use of clear aligners. The effects of aligner material properties, thickness, stress relaxation, staging protocols, and attachment design on the magnitude, direction, and predictability of force are discussed. The biomechanical properties of different tooth movements, such as tipping, bodily movement, rotation, intrusion, extrusion, torque and arch expansion are evaluated, highlighting limitations and opportunities for improving treatment outcomes. KEY WORDS:Clear aligner therapy (CAT) ,Orthodontic biomechanics ,Force delivery