Sergey N Rumyantsev

The Cancer War against the biggest current threat to global human health (1971 – 2???) failed dismally because the bankruptcy of its theoretical bases. New insights in cancer biology and origin are sorely needed. The goal of this article is to widen immunological evidence of the entirely innovative hypothesis of xenogamous origin, parasite subsistence and sexual transmission of human cancer. The search was based on a multidisciplinary integrative reassessment and reinterpretation of relevant current data about hereditary immunity of cancer and against cancer. The main focus was on manifestations of hereditary immunity over consecutive stages of cancer subsistence, beginning from the invasion of victim’s genome with cancerous gamete and finishing by sexual transmission of cancerous genome between people. The evidence of hereditary immunity has been revealed at any of the stages. The subsistence of cancer within a prey’s body at the expense of substances derived from the body is crucial for the progression of cancer. The subsistence is supported by constitutive immunity of cancer cells to the host’s immune defense and cell regulation. These new notions encourage new proposals for cancer prevention by restriction of cancerous fertilization and for cancer healing by pathogenetically grounded chemotherapy.