Mahboob Hasan

Granulomatous dermal lesions pose a diagnostic challenge, since several causes can produce an identical histologic picture and, conversely, a single cause may produce varied histologic pattern. The aim of this study is to analyze the spectrum of various etiologies involved in granulomatous skin diseases and their clinicopathological correlation. Cases of granulomatous lesions reported over last one year on histopathological and cytological examination were reviewed along with special stains. A total of 20 cases of different etiologies were taken for study including infectious and non-infectious underlying causes. Out of the 20 dermal granulomatous lesions studied, 12 cases (60.0%) were bacterial, 1 case (5%) each of fungal and associated with malignancy and 6 cases (30%) due to non-infectious etiology like granuloma annulare and foreign body associated were recorded. Amongst the bacterial granulomatous lesions, predominance of Mycobacterium leprae was seen, 6 cases (40%). The varied presentation of Hansen’s disease in our study included 4 cases (20%) of tuberculoid leprosy and 2 cases (10%) each of lepromatous leprosy and borderline tuberculoid leprosy. Three cases (15%) of cutaneous tuberculosis seen in our study and were typified as lupus vulgaris, 2 cases (10%) and a single case (5%) of tuberculosa verrucosa cutis. One case, (5%) of Klebsiella rhinoscleromatis was also seen. Skin biopsies help in arriving at a conclusive diagnosis, if aided by a proper clinical history and examination and assisted by special stains, culture of organisms, PCR and immunoflourescence.

Progress in the diagnosis and treatment of neoplasm in children in past few decades is one of the most gratifying achievement in the field of oncology. Childhood lymphomas are rare paediatric malignancy characterized by abnormal growth of lymphocytes. Aims and Objectives of this study was to describe the epidemiology of childhood cancer in western Uttar Pradesh, a state in Northern India, that would serve as a National reference source and will act as a seminal to spawn new research in the field of childhood lymphomas. The study evaluated a total of 252 cases of pediatric tumors over a period of seven years, including patient of 0-12 years of age group; attending the out-patients and in-patients of Jawaharlal Nehru Medical College (tertiary care centre), Aligarh, with the complaints of tumor associated sign and symptomsLymphoma being 3rd most common childhood malignancy in our study comprised a total of 15 cases, that included 9 cases of Hodgkin’s Lymphoma (HL) and 6 cases of Non Hodgkin’s Lymphoma (NHL). It accounted for 6% of total neoplasm and 12.5% of all pediatric malignancies. The mean age of occurrence was 8.1 years with a slight male predilection.