CH S Phani Kumar

Nabumetone is a non-steroidal anti-inflammatory agent preferred in the treatment of conditions and disorders associated with inflammation like osteoarthritis, rheumatoid arthritis and gout. The aim of the present study was to formulate HPMC matrix tablets coated with Eudragit S 100 and Eudragit L 100 for site-specific delivery of Nabumetone for treating spasms in colon. The use of enteric polymer Eudragit S 100 coated matrix tablets makes them able to release the drug at the particular pH of colonic fluid. The polymer Hydroxy propyl methyl cellulose K4M retards the drug release.