Published
Opinion: The Double Cause Hypothesis may explain environmental factors' effects associating with type 1 diabetes
Published in April 2026 Issue 4 (Vol. 13, Issue 4, 2026)

Abstract
We have shown the existence of permanent bubbles on Active hydrophobic Spot (AHS) at the luminal aspect of blood vessels.This led us to suggest the Double Cause Hypothesis (DCH) for autoimmune diseases when an autoantigen precursor spill into the blood and being deformed at gas/liquid interface to become autoantigen. Increased spillage of autoantigen precursor from β-cells due to enterovirus infection and elevated AHS due to lipids in the blood are suggested as environmental factors which increase the risk in acquiring T1DM. Further research lines are suggested.
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Authors (1)
Ran Arieli
Eliachar Research Laboratory, ...Eliachar Research Laboratory, Western Galilee Medi...Eliachar Research Laboratory, Western Galilee Medical Center, Nahariya...Eliachar Research Laboratory, Western Galilee Medical Center, Nahariya andThe Israel Naval Medical I...
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Article Information
Published in:
April 2026 Issue 4 (Vol. 13, Issue 4, 2026)BJMHR4130002
BJMHR-13-000003
7-13
2026-04-15
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Downloads:1,526
How to Cite
Arieli (2026). Opinion: The Double Cause Hypothesis may explain environmental factors' effects associating with type 1 diabetes. British Journal of Medical and Health Research, 13(4), 7-13. https://bjmhr.com/articles/BJMHR4130002
