Benzoic Acid Induced Pathological Alterations In Hepatic and Intestinal Cells of Rattus norvegicus

ABSTRACT Excess oral administration of Benzoic acid has been reported to have adverse effects on various organs. For present study, we aimed to assess putative hepatic and intestinal alterations if, repeatedly exposed to induced doses of benzoic acid against selected vertebrate animal model. Wistar rats were divided into five experimental groups as control, 30 days, 45 days, 60 days and 75 days respectively. Investigation was carried by were dividing animals into 5 groups. Group 1st is control group, while remaining 4 groups were treated with calculated dose of Benzoic acid (1.8 mg/ml/day or 45mg/25ml/day). Animals from all groups were sacrificed according to CPCSEA guideline. Understanding the paramount importance of liver and intestine the metabolism and as these organs are especially susceptible to toxicological damage. These organs were selected for histopathological investigation. Pathological investigations were interpreted for dependent biomechanics and behavioral changes in the experimental model Rattus norvegicus.