CLINICAL PROFILE AND TREATMENT OUTCOME OF CARCINOMA BREAST PATIENTS--- EXPEREINCE FROM A TERTIARY CARE HOSPITAL OF WESTERN UP

Background and Aims: The epidemiological data, management strategies and treatment outcomes for carcinoma breast patients were analyzed in patients admitted to a tertiary care hospital of western up. Materials and Methods: Hospital records of 399 patients admitted for over a period of five years (January 2011 to December 2015) were used for data analysis. Results: The maximum no. of pts presented was of 40-49 yrs age group (41.35%).66.6% pts were postmenopausal. The most common complaint was painless lump. Most of the patients (48.62%) presented to clinician after 1 yr of developing symptoms and only 5.51% pts within 3 mths of onset of symptoms. 68.41% pts presented as post op cases including residual and recurrent disease while 29.32% pts presented as locally advanced breast cancer. Familial breast cancer was very uncommon. Left sided breast cancer was slightly preponderant. The most common histology was infiltrating duct carcinoma.38.23% pts received adjuvant radiotherapy after receiving adjuvant chemotherapy.16.99% pts lost to follow up after completion of treatment. The 2yr DFS in the 3 arms (25#,20#,17#) was 44.68%,51.61% and 50% respectively, while 2 yrs overall survival was 61.7%,51.61% and 75% respectively. Loco-regional failures were seen in 0%, 3.22% and 12.5% cases and distal recurrence in 27.65%, 9.67% and 12.5 consecutively. While 5yrs overall survival in 25# vs. 20# arm was 9.7% vs. 4%. Conclusion: Mean age of presentation was found to be lower compared to the western world, with an average one decade before as mentioned in literature. Most of the patients were not having any risk factors except being female. Most of the patients got defaulted in view of long waiting list for radiotherapy so we are trying to switchover conventional protocol to hypo-fractionated Radiotherapy protocol so more no. of pts can be benefitted particularly in a government setup.