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British Journal of Medical and Health Research

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Biologic and Targeted Synthetic DMARDs Combined with Exercise Therapy in Rheumatoid Arthritis: A Scoping Review of Synergistic Effects and Functional Outcomes

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Published in November 2026 Issue 11 (Vol. 13, Issue 11, 2026)

Biologic and Targeted Synthetic DMARDs Combined with Exercise Therapy in Rheumatoid Arthritis: A Scoping Review of Synergistic Effects and Functional Outcomes - Issue cover

Keywords

activity; rehabilitation; ability to function; inflammatory arthritis; results of treatmentRheumatoid arthritisweak muscles

Abstract

Background: Rheumatoid arthritis is a long-term illness where medicines that change the course of the disease lower inflammation and stop damage from happening while exercise helps with being out of shape, weak muscles, trouble moving and heart problems. It is not clear if medicines that work on the system and exercise together have better results than either one on its own. Methods: This paper uses a way of looking at all the information called a scoping review. It brings together guidelines and published information about medicines, exercise and studies that look at both together. The draft does not say that a full search of all information has been done; the final people who write the paper should do the search check the information and record what they find before they submit it. Results: There is evidence that exercise works with regular care for rheumatoid arthritis especially for heart fitness, muscle strength, how well they can move and parts of feeling good. A study that looked at exercise with medicines found results on how active the disease was: some studies said the combination was better others showed no big difference and the way the studies were done stopped clear conclusions about a good combination. There is not information that is split up by the type of medicine. Exercise should usually go with not take the place of, medicine that tries to get the disease under control. The idea that exercise and the newer medicines work better together needs studies with clear plans for checking this standard ways to plan the exercise and important results that matter to people.

References

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  2. [2]2. Smolen JS, Landewé RBM, Bergstra SA, Kerschbaumer A, Sepriano A, Aletaha D, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2025 update. Ann Rheum Dis. 2026. doi:10.1016/j.ard.2026.01.023.
  3. [3]3. Rausch Osthoff AK, Niedermann K, Braun J, Adams J, Brodin N, Dagfinrud H, et al. 2018 EULAR recommendations for physical activity in people with inflammatory arthritis and osteoarthritis. Ann Rheum Dis. 2018;77(9):1251-1260. doi:10.1136/annrheumdis-2018-213585.
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  5. [5]5. Do disease-modifying anti-rheumatic drugs and exercise therapy have a combined effect on disease activity in patients with rheumatoid arthritis? A scoping review. Rheumatol Int. 2023. PMID:36867308. [Verify full author list, volume, pages, and DOI from the publisher/PubMed record before submission.]
  6. [6]6. Tricco AC, Lillie E, Zarin W, O'Brien KK, Colquhoun H, Levac D, et al. PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation. Ann Intern Med. 2018;169(7):467-473. doi:10.7326/M18-0850.
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Authors (3)

Shaik Abdul munaf

Sree Abirami college of Pharma...

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Muhammed siraj

sree abirami college of physio...

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Gnana karthikeyan.M

sree abirami college of physio...

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Article Information

Published in:

November 2026 Issue 11 (Vol. 13, Issue 11, 2026)

BJMHR11130003

BJMHR-13-000074

25-34

2026-11-02

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How to Cite

Abdul munaf, S., siraj, M., & karthikeyan.M, G. (2026). Biologic and Targeted Synthetic DMARDs Combined with Exercise Therapy in Rheumatoid Arthritis: A Scoping Review of Synergistic Effects and Functional Outcomes. British Journal of Medical and Health Research, 13(11), 25-34. https://bjmhr.com/articles/BJMHR11130003

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