Assessment of Lipid Profile among Healthy Sudanese Post Menopausal Ladies

Several changes occurs in menopausal phase in women which may lead to changes in metabolism of lipids, protein and carbohydrates. The objective of this study was to assess the concentration of total serum lipid profile, in pre and post menopausal Sudanese women. This is descriptive case control study carried in Babanosawestkord of an .One hundred (100) apparently healthy, non pregnant females (40premenopausal and 60 post menopausal) were recruited for the study. Serum total cholesterol and the fractions- high-density lipoproteins (HDL), low-density lipoproteins (LDL), and triglycerides (TG) were estimated using enzymatic and established mathematical methods. The (mean±SD)of total Cholesterol, HDL, LDL and Triglyceride in post menopause respectively were (159.5±14.5, 62.6± 8, 79.1± 9.7, 104.6±9.4).while The (mean ±SD)of total Cholesterol, HDL, LDL and Triglyceride in pre menopause Respectively were(137.2 ± 12.5, 84,8±6,5,31.7± 8,5,103.4 ±7.3). The results showed that there was significant difference in the total serum cholesterol between the two groups. There was however, a significant reduction of HDL in the postmenopausal group (P value <0.005) and a significant increase in the level of LDL in the postmenopausal group (P value <0.005). The elevated LDL and the reduction of cardio protective HDL is an indication that menopause is an independent risk factor for developing cardiovascular disease in our environment. There was no significant difference in the triglycerides between the two groups (p value > 005). The result was concluded that there was significant increase of total Cholestrol and low density lipoprotien LDL in post menopausal group ,also there was significant decrease of high density lipoprotien HDL when it compared with premenopuase group,(p value 0.00).Triglyceride remind unchanged and no significant difference between the pre and post menopausal groups( p value .517).