A Rare Case Of Hashimoto’s Encephalopathy Responding To Plasma Exchange

ABSTRACT Hashimoto’s encephalopathy is one of the rare causes of encephalopathy of unknown etiology. It manifests with neuropsychiatric symptoms. The estimated prevalence is 2/100,0001. Hashimoto’s encephalopathy is characterized by elevated antithyroid antibodies in absence of infections, tumors or stroke of central nervous system2-4. The disease manifests with wide array of clinical features which can be cognitive fluctuations, ataxia, myoclonus, seizures5-10. Psychitric manifestations like depression, mania, psychosis, and hallucinations have also been reported11-13. Anti thyroid antibodies are considered to be the biomarkers of the disorder but the titers of the antibodies do not correlate with the severity of the disease presentation 14-15. Keywords: Hashimoto’s encephalopathy, Hashimoto’s encephalopathy