risk of occurrence of cytomegalovirus infection in patients undergoing organ transplantation

Solid organ transplantation save lives in patients affected by terminal organ failures, improve quality of life and are essential for mature health care systems. Organ transplantation have gradually re-mediated in the last two decades and usually provide excellent results in children, young adults and elderly transplant patients with co-morbidities. However, complications such as infection and allograft rejection, which are related by immunosuppressive therapy, remain major causes of morbidity and mortality following solid organ transplantation. Infections are a major cause of morbidity and mortality in transplant recipients. Among various infections occurring after transplantation, cytomegalovirus is the most frequent and dangerous infection. Cytomegalovirus (CMV) continues to have a tremendous impact in solid organ transplantation despite remarkable advances in its diagnosis, prevention and treatment. It can affect allograft function and increase patient morbidity and mortality through a number of direct and indirect effects. This article reviews the effects of cytomegalovirus on various solid organ transplants, including prophylactic, diagnostic, treatment strategies by providing guidance regarding care of solid organ transplant patients with cytomegalovirus infection.