Abstract : Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women in the reproductive age. It is characterized by an ovulation manifested as oligomenorrhea or amenorrhea, elevated levels of androgens and luteinizing hormone (LH), and polycystic ovaries by ultrasound. PCOS also encompasses a broad spectrum of clinical, hormonal and ultrasonographic characteristics.The study was aimed to compare serum AMH levels between PCOS and normal women; and to investigate the relationship between AMH and testosterone.An analytical case control study implemented in Dr. Alser Abulehassan Center for Infertility, Khartoum. A number of 50 women with PCOS and a number of 30 healthy women were recruited for the study. Medical records were examined for patients who sought fertility consultation or treatment during the period from April 2015 till June 2015. The study protocol was approved by the Medical Ethical Committee of Alneelain University. AMH and Testosterone were significantly higher in the PCOS women in comparison to normal women. The AMH was positively correlated to Testosterone (r=.691, p<0.01), and negative correlation with body excessive hair (r= - 426, p< 0.05). Also negative correlation was found between infertility and excessive body hair (r= - 3.17, p< 0.05), while no correlation was found between AMH and women age and weight. Higher serum AMH and testosterone levels in PCOS women than in healthy women; and significant positive correlations between AMH and testosterone and in the PCOS women exclusively. AMH has been proposed as a marker of PCOS and as suggested to be useful initial diagnostic test for PCOS.
Keyword : ANTI-MULLERIAN-TESTOSTERONE, PCOS, Sudanese Women
pdf
Volume-11