1 Study of Uropathogen and its Antimicrobial Resistance Pattern from Tertiary Care Rural Hospital

Abstract : Urinary tract infections are serious health problem affecting 150 million people globally in each year. The distribution of antimicrobial susceptibility data of UTI-causing microorganisms changes from time to time and from place to place. So the present study was undertaken with the aim to study the microorganisms and their antimicrobial resistance patterns of microorganisms involved in UTIs. A total of 352 clinical specimens suspected of having UTIs were processed for identification of microorganisms and their antimicrobial resistance patterns of microorganisms involved in UTIs. A total of 221(62.78%) bacterial uropathogens were isolated. E.coli was the dominant bacteria among all isolated uropathogens with the prevalence rate of 42.08%. The second most prevalent isolate was S.aureus 62(28.05%).The prevalence of UTI is more among females 143(71.5%) as compared to males 78(51.32%). Female to male ratio was 1.83:1 E.coli is the predominant organism in the age group of 21-40 and in 81-90 years. The prevalence of S.aureus and P.aeruginosa were higher in the extreme age groups. The percentage of uropathogens in the geriatric age group was 80.52% Ward-wise, majority of the isolates were from Surgery(69.23%) and obgyn(69.49%). Isolate wise, Higher prevalence of E.coli were from Medicine (38.85%) and OPD (32.73%) and that of Staphylococcus aureus were seen in Obgy(32.20%),ICU(24.14%) and Surgery(23.08%) and pediatric wards whereas from other wards E.coli was predominant. Uropathogens showed higher resistance to fluoroquinolones and lower resistance was seen to aminoglycoside. In conclusion, although E.coli is the predominant isolate causing UTI, the pathogen that is gaining significance is S.aureus.

Keyword : Urinary tract infections, uropathogens, antimicrobial resistance