British Journal of Medical and Health Research BJMHR 2394-2967 10.5281/zenodo.7878520 BJMHR1004005 Implant loss in Diabetic Patients: A Systematic Review Khalifa Mohamed T. ElKhashab Mohamed Amr M.H.Nasouhy Nagla Radi Iman Abd-ElWahab MSc Student, Prosthodontics department, Faculty of Dentistry, Cairo University, Cairo, Egypt. Lecturer of Prosthodontics, Faculty of Dentistry, Cairo University, Cairo, Egypt. Associate Professor of Prosthodontics, Faculty of Dentistry, Cairo University, Cairo, Egypt. Professor of Prosthodontics, Member of Evidence Based dentistry Center, Head of Fundraising Unit, Head of Central Control Unit, Faculty of Dentistry, Cairo University, Cairo, Egypt. 04 01 2023 10 4

ABSTRACT The aim of this systematic review to evaluate the effect of diabetes on dental implants loss. Review authors searched 3 electronic databases; Pubmed, Cochrane and Lilacs: 11/10/2018, hand searched 11 journals till November 2018 and snowballing: 15/10/2018. Adult female and male patients above 18 years old, either completely or partially edentulous, maxillary and/or mandibular dental implants, restored by fixed or removable prosthesis, were included. Surgical modifications, drugs that affect bone density, like vitamin D and biphosphonates, were excluded. Diabetic patients, who are classified either controlled or uncontrolled were considered eligible. Review authors extracted data relevant to PECOT. Data was descriptively and statistically analyzed. 14 studies; 9 prospective and 5 retrospective studies, involving 1398 participants and 3282 implants, were included in this systematic review. 3 studies were included in the meta-analysis. Based on the results of implant loss 2 years following implant placement, implant therapy in diabetic patients seems to be possible. However, results should be taken with extreme cautions, since the quality of evidence is very low. Keywords: Diabetes mellitus, high blood sugar, Dental implants, Oral implants

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