British Journal of Medical and Health Research BJMHR 2394-2967 10.46624/bjmhr.2021.v8.i4.003 BJMHR0804003 AMELIORATIVE EFFECTS OF METHANOL EXTRACT OF ENGLERINA DRUMMONDII (MISTLETOE) LEAVES ON DIABETES MELLITUS-INDUCED HYPERGLYCAEMIA AND TESTICULAR DYSFUNCTION IN MALE WISTAR RATS Adienbo Ologhaguo Macstephen Hart Victor Opuada Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Port Harcourt, Port Harcourt Nigeria Department of Human Physiology, College of Health Sciences, University of Port Harcourt, Port Harcourt, Nigeria. 04 01 2021 8 4

Diabetes mellitus affects more than 100 million worldwide, with a soaring prevalence. Prolonged diabetes results in reproductive dysfunction. Mistletoe is widely used in ethnomedicine, including treatment of infertility. This study is aimed at evaluating effect of Englerina drummondi (mistletoe) leaves on testicular function in diabetic male rats. Methanol Extract of Englerina drummondii Leaves (MEDL) was obtained by soxhlet extraction. Thirty male Wistar rats (170–200 g) were grouped into 6 (A – F; n=5). Diabetes Mellitus (DM) was induced in groups D, E and F by administration of 250mg/kg fructose and High Fat Diet (HFD) for 6 weeks. Thereafter, rats in all groups were treated orally for 56 days with either MEDL or Distilled Water (DW) as follows: Group A (control) 1ml DW; B (500mg/kg MEDL), C (250mg/kg MEDL), D (DM + 250mg/kg MEDL), E (DM + 500mg/kg MEDL), F (DM + 1 ml DW; served as diabetic control). Fasting Blood Glucose (FBG) measured on weeks 0, 2, 4, 6 and 8. After treatment, rats were sacrificed, blood collected and serum used for testosterone; epididymal semen for sperm analysis. Results show that MEDL significantly (P

 Englerina drummondii mistletoe Diabetes mellitus Sperm quality testicular dysfunction