The aim of the study is to examine the preventive effects of drugs given before Nd:YAG capsulotomy to prevent transient IOP spike occurring after the procedure.130 patients were included in the study and their IOP were recorded one hour prior to the procedure and then after the procedure at predetermined timings. Patients were divided into two groups based on the drop brimonidine or timolol instilled in their eyes before the procedure. The changes in the IOP were compared in between the two groups, In the results we found that both the drugs lowered IOP after two hours with brimonidine having values 12.86 ± 3.35 and timolol with 13.35 ±5.25. However, both the drugs lowered the IOP to values below the recorded ones at the commencement of the procedure but did not show any significant difference amongst themselves. Hence, to summarize the study we found that both the drugs decrease the transient IOP spike so as to prevent chances of glaucoma development in the patient.