British Journal of Medical and Health Research BJMHR 2394-2967 10.46624/bjmhr.2018.v5.i10.004 BJMHR0510004 Role of D-dimer in Predicting Severity and Mortality of Community-acquired Pneumonia Miteva Darina Nikolova Dimitrov Yordan Radkov Stefanova Vanya Kostadinova Medical University - Varna, Bulgaria Department of Pulmonology and Allergology Head of Department of Pulmonology and Allergology, Medical University of Varna, Bulgaria Head of Clinic of Pneumonology and Phthisiatrics, MHAT”St. Marina”- Varna, Bulgaria Department of Pulmonology and Allergology, Medical University of Varna, Bulgaria Clinic of Pneumonology and Phthisiatrics, MHAT”St. Marina”- Varna, Bulgaria 10 01 2018 5 10

Introduction: Coagulation disturbances are one of the markers of systemic inflammation. Aim: To evaluate the role of D-dimer (DD) in predicting severity and mortality of hospitalized patients with community-acquired pneumonia. Material and Methods:143 CAP patients hospitalized in the Clinic of Pneumology and Phthisiatrics at “Saint Marina” University Hospital were retrospectively studied. D-dimer was measured on admission by latex-enhanced immunoturbidimetric method with reference value of 0,232mg/L. The severity of CAP was determined by PSI, CURB-65 and IDSA/ATS criteria. Results: Patients were on mean age 62.12±15.54 years, 59.4% - male. Elevated levels of D-dimer were found in 86.70% of the patients. The mean DD in non-survivors was significantly higher than in survivors (2.19±2.01mg/L vs. 1.28±1.46mg/L, р

 CAP D-dimer severity mortality