British Journal of Medical and Health Research

BJMHR

2394-2967

BJMHR0308004

Formulation & Evaluation of Nabumetone Enteric Coated Tablets

Kumar

CH S Phani

Suma

Dwarampudi

Lalitha

Medisetti

VJ's College of Pharmacy Aditya College of Pharmacy, Faculty of Pharmaceutical Technology, Department of Pharmaceutics, Surampalem, India

08 01 2016

3 8

Nabumetone is a non-steroidal anti-inflammatory agent preferred in the treatment of conditions and disorders associated with inflammation like osteoarthritis, rheumatoid arthritis and gout. The aim of the present study was to formulate HPMC matrix tablets coated with Eudragit S 100 and Eudragit L 100 for site-specific delivery of Nabumetone for treating spasms in colon. The use of enteric polymer Eudragit S 100 coated matrix tablets makes them able to release the drug at the particular pH of colonic fluid. The polymer Hydroxy propyl methyl cellulose K4M retards the drug release.

Nabumetone HPMC K4M Eudragit L 100 & S 100 Enteric coated tablets