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  <front>
    <journal-meta>
      <journal-title-group>
        <journal-title>British Journal of Medical and Health Research</journal-title>
        <abbrev-journal-title abbrev-type="publisher">BJMHR</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="epub">2394-2967</issn>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">BJMHR0307004</article-id>
      <title-group>
        <article-title>Effects of prolonged oral administration of sildenafil citrate on wound healing of diabetic rats</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Umaru</surname>
            <given-names>Bukar</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Ngulde</surname>
            <given-names>S I</given-names>
          </name>
          <xref ref-type="aff" rid="aff2"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Mahre</surname>
            <given-names>M B</given-names>
          </name>
          <xref ref-type="aff" rid="aff2"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>William</surname>
            <given-names>A</given-names>
          </name>
          <xref ref-type="aff" rid="aff2"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Middah</surname>
            <given-names>Y H</given-names>
          </name>
          <xref ref-type="aff" rid="aff2"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Atela</surname>
            <given-names>E P</given-names>
          </name>
          <xref ref-type="aff" rid="aff2"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Agbutun</surname>
            <given-names>P A</given-names>
          </name>
          <xref ref-type="aff" rid="aff2"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Bukar</surname>
            <given-names>A M</given-names>
          </name>
          <xref ref-type="aff" rid="aff2"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Bashir</surname>
            <given-names>M M</given-names>
          </name>
          <xref ref-type="aff" rid="aff2"/>
        </contrib>
      </contrib-group>
      <aff id="aff1">University of Maiduguri, Maiduguri. Borno State. Nigeria.</aff>
      <aff id="aff2">Department of Veterinary Physiology, Pharmacology and Biochemistry, University of Maiduguri, P.M.B. 1069, Maiduguri,Borno state, Nigeria.</aff>
      <pub-date pub-type="epub" iso-8601-date="2016-07-01">
        <month>07</month>
        <day>01</day>
        <year>2016</year>
      </pub-date>
      <volume>3</volume>
      <issue>7</issue>
      <abstract>
        <p>Wound healing is a major problem in diabetic patient. Sildenafil citrate was earlier reported as a pro-angiogenic agent found to stimulate angiogenesis. We decided to investigate if oral administrations of sildenafil citrate in type I diabetic rats will enhance wound healing. The study was performed using fourty two rats (42) weighing between 139-225 grams. The rats were grouped A-G, six (6) rats per group. Wound area of 1.5 by 1.5 cm2 was created at the dorsal surface of each rat under sedation with ketamine and local anaesthetic (lignocaine). Type I diabetes was induced using Alloxan monohydrate at dose rate of 130 mg/kg.  Sildenafil citrate was administered at a dose rate of 50 mg/kg orally daily for 21 days and 10 international units of insulin was administered intraperitoneally to the control group once. Blood glucose and platelet count were significantly (p0.05) decrease as compared to day 3 in diabetic rats. We concluded that oral administration of sildenafil citrate at dose rate of 50 mg/kg did not significantly enhance wound healing in diabetic rats.</p>
      </abstract>
      <kwd-group kwd-group-type="author">
        <kwd>Sildenafil citrate</kwd>
        <kwd>diabetic</kwd>
        <kwd>wound healing</kwd>
        <kwd>rats</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
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