The present study aimed to investigate the effect of antivenom of Echis carinatus sochureki snake on sex hormones, immunological and sperm parameters of male rats. Adult male rats divided into three groups (6 for each group), the first group injected (I.P.) with normal saline (0.9%Nacl) as a control group, the second group injected with (0.25ml/kg/day) of antivenom for two times, and the third group injected with (0.5ml/kg/day) of antivenom for two times. Animals killed within 24 hours. The results indicated a significant increase (PË‚0.05) in the level of FSH, LH and testosterone in second and third groups compared with the first group. IgG, IgM and IgA increased significantly in male and female rats of second and third groups compared with the control group within 24 hr. The injection of antivenom of the Echis carinatus induced a significant decrease in sperm countof second and third groups compared with the control group, and