Moringa oleifera is one of the many plants used today for treating various pathological conditions. The aim of the present study is to investigate the effects of Moringa oleifera leaf on blood glucose, blood pressure and temperature in normal conditions. The study is divided into two independent phases: acute phase and chronic phase. 34 participants took part in the acute phase. Subjects in this phase were divided into 5 groups of 6-8 participants. Group 1 was given water only, Group 2 received 75g oral glucose load and 2 hours later was given 75mg/kg dose of M. oleifera, Group 3 was given 75mg/kg dose of M. oleifera and received 75g oral glucose load 2 hours later. Group 4 was given 75g oral glucose load only, Group 5 received 75mg/kg M. oleifera only. Baseline readings for blood pressure, pulse rate and body temperature were taken for groups 1 to 4 in their fasting state, while group 5 baseline readings were taken as random blood glucose. 16 participants divided into two groups took part in the chronic phase of the study. Group 6 subjects received 37.5mg/kg doses while Group 7 received 75mg/kg doses of M. oleifera. M. oleifera decreased blood pressure significantly (P