Major depressive disorder is usual in patients experiencing an episode of myocardial infarction. Different coronary heart disease risk factors do influence the chances of occurrence of post-Myocardial Infarction Depression.The purpose of this work was to test the influence of various coronary heart disease risk factors on the chances of occurrences of the post-Myocardial Infarction Depression.The study was conducted on Patients of Acute myocardial infarction (n=100) attending cardiology Out Patient Department of Assam medical college, Dibrugarh, Assam in 4 to 6 weeks after the index event. The screening was done by The Primary Care Evaluation of Mental Disorders and diagnoses of Major Depressive Disorder were established according to the Diagnostic and Statistical Manual for Mental Disorders fourth edition Test Revision criteria. The severity of the depression was assessed by Beck Depression Inventory. Logistic regression analysis was utilized for the analysis.Among the four coronary risk factor variables past history of Myocardial Infarction was found to be influencing the chances of occurrence of post-MI depression ( p = 0.015, Wald = 5.910).Persons having past history of Myocardial Infarction are more susceptible to develop post-Myocardial Infarction Depression.