Stroke is a serious condition in which specific area of the brain will loss the blood supply. When blood restored to the ischemic area the risk will be increased and brain cells will undergo cell death by the two known forms of cell death (apoptosis and necrosis). Methionine is an essential amino acid needed by our body for many physiological pathways like synthesis of glutathione which is considered as more important endogenous antioxidant molecules. This study was designed to assess the possible neuroprotective activity of L-Methionine in cerebral I/R injury after bilateral common carotid artery occlusion (BCCAO) in rats. A total of 24 Adult Sprague-Dawley rats were used. They divided equally into four groups (sham, control, control vehicle and L-methionine treated groups). Their brains were removed and prepared by a reported procedure for histopathological study and staining with 2, 3, 5-triphenyltetrazolium chloride (TTC). It has been found that both histopathological and TTC staining results showed a significant role for L-Methionine as cerebroprotective agent and further studies are recommended to confirm that.