This is a case control study. It was conducted at Madani educational Hospital in Aljazeera state. The aim of the present study is to evaluate Serum urea, creatinine, Na, K, copper and selenium levels in sickle cell disease patients. A total of 70 sickle cell disease patients were enrolled in this study, in addition to 30 healthy’ children as a control group age and sex matched apparently healthy control subjects. Blood samples collected from participants were analyzed for trace elements using atomic absorption spectrophotometer. The results of the present study showed a significant increase in the mean of serum urea levels in patients when compared with control group (58.76±10.19) versus (34.27±7.13) mg/dl respectively with (P-value 0.00). Result of creatinine indicated insignificant increase when compared mean of patients with mean of control group (0.87±0.22) versus (0.42±0.07) mg/dl with (P-value 0.07). Also there was insignificant difference in the serum Na and K in mean of patients comparing with mean of control group (138.77±6.47) versus (139.5±2.93)m.mol/l (P-value 0. 5), (4.28±0.74) versus (3.91±0.34) m. mol/l (P-value 0.10). In the current study there was significant increase in the mean of serum copper levels when compared mean of patients with mean of control group(1.61±0.22) versus (1.03±0.23) mg/ L (P-value 0.00) but in the mean of serum selenium levels there was a significant decrease(64.91 ± 3.780) versus (85.40±8.82) (P-value 0.00). Conclusively, assessment of trace element levels is vital in the management of sickle cell disease. and thereby improving the chances of survival in sickle cell disease.